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  1. Article

    Open Access

    Priority index for critical Covid-19 identifies clinically actionable targets and drugs

    While genome-wide studies have identified genomic loci in hosts associated with life-threatening Covid-19 (critical Covid-19), the challenge of resolving these loci hinders further identification of clinically...

    Zhiqiang Zhang, Shan Wang, Lulu Jiang, Jianwen Wei, Chang Lu… in Communications Biology (2024)

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  2. Article

    Open Access

    Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects

    Increasing numbers of SARS-CoV-2-positive (SARS-CoV-2pos) subjects are detected at silent SARS-CoV-2 infection stage (SSIS). Yet, SSIS represents a poorly examined time-window wherein unknown immunity patterns ma...

    Shanhe Yu, Caixia Di, Shijun Chen, Mingquan Guo, Jiayang Yan, Zhaoqin Zhu… in Cell Research (2021)

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  3. Article

    Open Access

    Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19

    The pathophysiology of coronavirus disease 19 (COVID-19) involves a multitude of host responses, yet how they unfold during the course of disease progression remains unclear. Here, through integrative analysis...

    Yun Tan, Wei Zhang, Zhaoqin Zhu, Niu Qiao, Yun Ling, Mingquan Guo… in Cell Discovery (2021)

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  4. Article

    Open Access

    A large-scale evaluation of computational protein function prediction

    A report on the results of the first large-scale community-based critical assessment of protein function annotation (CAFA) experiment.

    Predrag Radivojac, Wyatt T Clark, Tal Ronnen Oron, Alexandra M Schnoes… in Nature Methods (2013)

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