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Open AccessHigh-efficiency reinforcement learning with hybrid architecture photonic integrated circuit
Reinforcement learning (RL) stands as one of the three fundamental paradigms within machine learning and has made a substantial leap to build general-purpose learning systems. However, using traditional electr...
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Open AccessA longitudinal resource for population neuroscience of school-age children and adolescents in China
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...
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Open AccessPublisher Correction: Soil contamination in nearby natural areas mirrors that in urban greenspaces worldwide
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Open AccessSoil contamination in nearby natural areas mirrors that in urban greenspaces worldwide
Soil contamination is one of the main threats to ecosystem health and sustainability. Yet little is known about the extent to which soil contaminants differ between urban greenspaces and natural ecosystems. He...
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Open AccessTracking westerly wind directions over Europe since the middle Holocene
The variability of the northern westerlies has been considered as one of the key elements for modern and past climate evolution. Their multiscale behavior and underlying control mechanisms, however, are incomp...
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Open AccessDissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the transcriptome of 113 single CTCs from 4...
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Open AccessA new coronavirus associated with human respiratory disease in China
Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health1–3. Despite intense research efforts, how, when and where new disease...
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Open AccessResequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil
As Charles Darwin anticipated, living fossils provide excellent opportunities to study evolutionary questions related to extinction, competition, and adaptation. Ginkgo (Ginkgo biloba L.) is one of the oldest liv...
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Open AccessExperimental test of fine-grained entropic uncertainty relation in the presence of quantum memory
The uncertainty principle, which gives the constraints on obtaining precise outcomes for incompatible measurements, provides a new vision of the real world that we are not able to realize from the classical kn...
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Open AccessParkinson disease with constipation: clinical features and relevant factors
Constipation is one of the most frequent non-motor symptoms of Parkinson disease (PD) and it may be ignored by PD patients, leading to this problem not to be reported in time. The relationships between constip...
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Open AccessPredicting the Origin of Ventricular Arrhythmia Using Acoustic Cardiography
This study aimed to examine the relationship between measurements related to heart sounds and the origin of ventricular arrhythmia. We retrospectively evaluated 45 patients undergoing catheter ablation with co...
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Open AccessRestless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters
Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 patients into PD with an...
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Open AccessGeometric quantum discords of interacting qubits in thermal reservoir
We examined decay dynamics of various geometric quantum discords (GQDs) for two interacting qubits described by the Heisenberg XY model and further coupled independently to their respective thermal reservoirs. Co...
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Open AccessAs a carrier–transporter for hair follicle reconstitution, platelet-rich plasma promotes proliferation and induction of mouse dermal papilla cells
Morphogenesis of hair follicles during development and in hair reconstitution assays involves complex interactions between epithelial cells and dermal papilla cells (DPCs). DPCs may be a source of cells for ha...
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Open AccessPhenotype of postural instability/gait difficulty in Parkinson disease: relevance to cognitive impairment and mechanism relating pathological proteins and neurotransmitters
Parkinson disease (PD) is identified as tremor-dominant (TD) and postural instability and gait difficulty (PIGD) phenotypes. The relationships between motor phenotypes and cognitive impairment and the underlyi...
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Open AccessSerotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease
Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and...
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Open AccessThe genetic map of goldfish (Carassius auratus) provided insights to the divergent genome evolutions in the Cyprinidae family
A high-density linkage map of goldfish (Carassius auratus) was constructed using RNA-sequencing. This map consists of 50 linkage groups with 8,521 SNP markers and an average resolution of 0.62 cM. Approximately 8...
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Open AccessMicroRNA-122 as a predictor of HBsAg seroclearance in hepatitis B and C dual infected patients treated with interferon and ribavirin
It has been demonstrated that microRNA-122 (miR-122) plays key roles in the modulation of hepatitis B virus (HBV) replication. This study examined the role of miR-122 in patients with hepatitis C virus (HCV)-H...
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Open AccessExogenous N addition enhances the responses of gross primary productivity to individual precipitation events in a temperate grassland
Predicted future shifts in the magnitude and frequency (larger but fewer) of precipitation events and enhanced nitrogen (N) deposition may interact to affect grassland productivity, but the effects of N enrich...
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Open AccessDisruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation
Physical and chemical insult-induced bone marrow (BM) damage often leads to lethality resulting from the depletion of hematopoietic stem and progenitor cells (HSPCs) and/or a deteriorated BM stroma. Notch sign...