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Reply to the c-kit(CD117) sequence variation M541L, but not N564K, is frequent in the general population, and is not associated with CML in Caucasuans by Stefan Kruger et al.
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Abnormality of c-kit oncoprotein in certain patients with chronic myelogenous leukemia – potential clinical significance
Chronic myelogenous leukemia (CML) is characterized by the Philadelphia (Ph) chromosome and bcr/abl gene rearrangement which occurs in pluripotent hematopoietic progenitor cells expressing the c-kit receptor t...