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Article
Kidney lesions in rats with severe long-term alloxan diabetes
Alloxan diabetes was induced in rats by intraperitoneal injection or by injection into the vena cava. In 3 groups the renal vessels were clamped during, and for some minutes after, the injection. The histologi...
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Article
Second Annual Meeting of the European Association for the Study of Diabetes abstracts
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Article
Scandinavian Society for the Study of Diabetes abstracts
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Article
Fourth meeting of the Scandinavian Society for the Study of Diabetes Stockholm, February 1–3, 1968 Abstracts
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Article
Seventh Annual Meeting of the European Association for the Study of Diabetes
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Article
Annual Meeting of the Scandinavian Society for the Study of Diabetes
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Article
The excretion of insulin in urine
The concentration of biologically active insulin was measured by the isolated fat cell method in serum and urine from healthy subjects and compared with the concentration of immunoreactive insulin. In both uri...
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Article
Book reviews
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Article
Characterisation of somatostatin release from the pancreas
The effect of calcium on somatostatin secretion was investigated in the isolated, perfused canine pancreas preparation and compared with those of acetylcholine, glucose, isoproterenol and arginine. Calcium (5 ...
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Article
Streptozotocin diabetes: A glucoreceptor dysfunction affecting D cells as well as B and A cells
Somatostatin release from the isolated pancreas of 3 normal and 6 streptozotocin diabetic dogs has been measured in response to various stimuli to determine whether abnormalities in somatostatin release are pr...
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Article
Absorption of human growth hormone injected subcutaneously and intramuscularly in growth deficient dwarfs
Hunan growth hormone (HGH) is commonly administrated by i.m. injections. The high purity of the present HGH preparations makes s.c. administration an attractive alternative enabling self-administration. In thi...
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Article
Kidney function and size in type 1 (insulin-dependent) diabetic patients before and during growth hormone administration for one week
Kidney function and size were studied in seven well-controlled male Type 1 (insulin-dependent) diabetic patients before and after administration of highly purified human growth hormone for one week. Glomerular...
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Article
The metabolic and hormonal response to acute normoglycaemia in type 1 (insulin-dependent) diabetes: Studies with a glucose controlled insulin infusion system (artificial endocrine pancreas)
Twelve insulin deficient Type 1 (insulin-dependent) diabetic subjects were studied over an 11 1/2 h period during both subcutaneous insulin therapy and closed loop insulin delivery, using a glucose controlled ...
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Article
The metabolic effects of dopamine in man
The metabolic effects of dopamine have been investigated by its infusion in normal man with and without simultaneous somatostatin administration. Dopamine was infused into overnight fasted men at 1.5 µg/kg/min (n
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Article
A comparison of the artificial pancreas (glucose controlled insulin infusion system) and a manual technique for assessing insulin sensitivity during euglycaemic clam**
Two main methods are available for assessing insulin sensitivity with the hyperinsulinaemic euglycaemic clamp technique: one employs a glucose-controlled insulin infusion system (the Biostator) with automatic ...
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Article
FERTILITY AND SEMEN QUALITY IN PREVIOUSLY GROWTH HORMONE TREATED MEN
32 men aged 20-35 years (median 27.3 years) who were treated in childhood or adolescence with growth hormone participated in the study. Sixteen had isolated growth hormone deficiency and 16 panhypopituitarism ...
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Article
GROWTH HORMONE SECRETION AFTER CLONIDINE STIMULATION TEST IN PREVIOUSLY TREATED GROWTH HORMONE DEFICIENT CHILDREN
Thrirty-four previously growth hormone treated persons aged 17 to 35 years, diagnosed in childhood as growth hormone deficient with insulin hypoglycaemia and growth hormone peak concentrations <7 ng/ml, were r...
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Article
THE METABOLIC CLEARANCE RATE, APPARENT DISTRIBUTION SPACE AND PLASMA HALF-LIFE OF UNLABELLEO BIOSYNTHETIC HUMAN GROWTH HORMONE IN HYPOPITUITARY PATIENTS
Previously published information on GH metabolism in GH-deficient patients is scarce and data are conflicting. We studied the metabolic clearance rate (MCR), plasma half-life (T1/2) and apparent distribution spac...
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Article
EVIDENCE OF LOCAL DEGRADATION OF SUBCUTANEOUSLY INJECTED BIOSYNTHETIC HUMAN GROWTH HORMONE IN HYPOPITUITARY PATIENTS
In a previous study we observed that subcutaneously (s.c.) injected human growth hormone (hGH) resulted in significantly lower serum growth hormone profiles (AUC) than after intramusculary (i.m.) administratio...
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Chapter and Conference Paper
Observations During a Clinical Trial of Sandostatin® in Acromegalic Patients
Ten acromegalic patients were studied over a period of 75 weeks. Four had had one or more attempted ablations of their pituitary adenoma, six were previously untreated or had been unsuccessfully treated with b...
