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Article
Increased levels of circulating free insulin-like growth factors in patients with non-islet cell tumour hypoglycaemia
Non-islet cell tumour hypoglycaemia (NICTH) is characterised by severe and recurrent fasting hypoglycaemia, and is usually caused by secretion of insulin-like growth factor-II (IGF-II) by the tumour. This ind...
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Article
Effect of octreotide and insulin on manifest renal and glomerular hypertrophy and urinary albumin excretion in long-term experimental diabetes in rats
Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes incr...
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Article
Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats
The insulin-like growth factors, insulin-like growth factor I and insulin-like growth factor II are bound to six distinct classes of insulin-like growth factor binding proteins (IGFBPs) in the circulation and ...
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Article
Effect of insulin-like growth factor I infusion on renal hypertrophy in experimental diabetes niellitus in rats
Initial diabetic renal hypertrophy is preceded by a transient increase in kidney insulin-like growth factor I suggesting that insulin-like growth factor I may be implicated in diabetic kidney growth. The prese...
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Article
Renal insulin-like growth factor I and growth hormone receptor binding in experimental diabetes and after unilateral nephrectomy in the rat
We have measured specific binding of insulin-like growth factor I and growth hormone to renal plasma membranes from control, streptozotocin-diabetic, insulin-treated diabetic, uninephrectomised and combined di...
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Article
Kidney IGF-I mRNA in initial renal hypertrophy in experimental diabetes in rats
It has recently been demonstrated that immunoassayable kidney insulin-like growth factor I concentration increases 24–48 h after induction of diabetes, preceding the initial renal hypertrophy. To elucidate whe...
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Article
Somatostatin analogue administration prevents increase in kidney somatomedin C and initial renal growth in diabetic and uninephrectomized rats
In a previous study we demonstrated that the kidney content of somatomedin C was maximal one to two days after uninephrectomy or induction of diabetes, and that insulin treatment prevented an increase in kidne...
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Article
96 DOSE-RESPONSE STUDIES WITH BIOSYNTHETIC HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT PATIENTS
Increasing doses of biosynthetic human growth hormone (B-hGH) were given subcutaneously to 7 GH deficient subjects for three 14 days periods (2, 4 and 6 IU/day at 20.00 h) followed by 14 days without GH therap...
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Article
41 EVIDENCE THAT POTASSIUM DEFICIENCY INDUCES GROWTH RETARDATION THROUGH REDUCED SOMATOMEDIN C PRODUCTION
Growth retardation and impaired protein synthesis are major characteristics in potassium (K) depletion in animals and man. After K-repletion serum and muscle contents of K are normalized within few hours, whil...
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Article
Kidney tissue somatomedin C and initial renal growth in diabetic and uninephrectomised rats
Kidney growth after induction of experimental diabetes in rats was compared to compensatory renal growth in response to unilateral nephrectomy. After 4 days of diabetes, kidney weight had increased from 816±21...
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Article
FERTILITY AND SEMEN QUALITY IN PREVIOUSLY GROWTH HORMONE TREATED MEN
32 men aged 20-35 years (median 27.3 years) who were treated in childhood or adolescence with growth hormone participated in the study. Sixteen had isolated growth hormone deficiency and 16 panhypopituitarism ...
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Article
GROWTH HORMONE SECRETION AFTER CLONIDINE STIMULATION TEST IN PREVIOUSLY TREATED GROWTH HORMONE DEFICIENT CHILDREN
Thrirty-four previously growth hormone treated persons aged 17 to 35 years, diagnosed in childhood as growth hormone deficient with insulin hypoglycaemia and growth hormone peak concentrations <7 ng/ml, were r...
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Article
THE METABOLIC CLEARANCE RATE, APPARENT DISTRIBUTION SPACE AND PLASMA HALF-LIFE OF UNLABELLEO BIOSYNTHETIC HUMAN GROWTH HORMONE IN HYPOPITUITARY PATIENTS
Previously published information on GH metabolism in GH-deficient patients is scarce and data are conflicting. We studied the metabolic clearance rate (MCR), plasma half-life (T1/2) and apparent distribution spac...
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Article
EVIDENCE OF LOCAL DEGRADATION OF SUBCUTANEOUSLY INJECTED BIOSYNTHETIC HUMAN GROWTH HORMONE IN HYPOPITUITARY PATIENTS
In a previous study we observed that subcutaneously (s.c.) injected human growth hormone (hGH) resulted in significantly lower serum growth hormone profiles (AUC) than after intramusculary (i.m.) administratio...
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Article
A comparison of the artificial pancreas (glucose controlled insulin infusion system) and a manual technique for assessing insulin sensitivity during euglycaemic clam**
Two main methods are available for assessing insulin sensitivity with the hyperinsulinaemic euglycaemic clamp technique: one employs a glucose-controlled insulin infusion system (the Biostator) with automatic ...
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Article
The metabolic and hormonal response to acute normoglycaemia in type 1 (insulin-dependent) diabetes: Studies with a glucose controlled insulin infusion system (artificial endocrine pancreas)
Twelve insulin deficient Type 1 (insulin-dependent) diabetic subjects were studied over an 11 1/2 h period during both subcutaneous insulin therapy and closed loop insulin delivery, using a glucose controlled ...
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Article
Kidney function and size in type 1 (insulin-dependent) diabetic patients before and during growth hormone administration for one week
Kidney function and size were studied in seven well-controlled male Type 1 (insulin-dependent) diabetic patients before and after administration of highly purified human growth hormone for one week. Glomerular...
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Article
Absorption of human growth hormone injected subcutaneously and intramuscularly in growth deficient dwarfs
Hunan growth hormone (HGH) is commonly administrated by i.m. injections. The high purity of the present HGH preparations makes s.c. administration an attractive alternative enabling self-administration. In thi...
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Article
Streptozotocin diabetes: A glucoreceptor dysfunction affecting D cells as well as B and A cells
Somatostatin release from the isolated pancreas of 3 normal and 6 streptozotocin diabetic dogs has been measured in response to various stimuli to determine whether abnormalities in somatostatin release are pr...
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Article
Characterisation of somatostatin release from the pancreas
The effect of calcium on somatostatin secretion was investigated in the isolated, perfused canine pancreas preparation and compared with those of acetylcholine, glucose, isoproterenol and arginine. Calcium (5 ...
