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  1. Article

    96 DOSE-RESPONSE STUDIES WITH BIOSYNTHETIC HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT PATIENTS

    Increasing doses of biosynthetic human growth hormone (B-hGH) were given subcutaneously to 7 GH deficient subjects for three 14 days periods (2, 4 and 6 IU/day at 20.00 h) followed by 14 days without GH therap...

    J O L Jørgensen, A Flyvjerg, T Lauritzen, H Ørskov, J S Christiansen… in Pediatric Research (1988)

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  2. Article

    41 EVIDENCE THAT POTASSIUM DEFICIENCY INDUCES GROWTH RETARDATION THROUGH REDUCED SOMATOMEDIN C PRODUCTION

    Growth retardation and impaired protein synthesis are major characteristics in potassium (K) depletion in animals and man. After K-repletion serum and muscle contents of K are normalized within few hours, whil...

    A Flyvbjerg, I Dørup, M E Everts, T Clausen, H Ørskov in Pediatric Research (1988)

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  3. Article

    FERTILITY AND SEMEN QUALITY IN PREVIOUSLY GROWTH HORMONE TREATED MEN

    32 men aged 20-35 years (median 27.3 years) who were treated in childhood or adolescence with growth hormone participated in the study. Sixteen had isolated growth hormone deficiency and 16 panhypopituitarism ...

    S A Pedersen, J O Jørgensen, J S Christiansen, H Ørskov… in Pediatric Research (1988)

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  4. Article

    GROWTH HORMONE SECRETION AFTER CLONIDINE STIMULATION TEST IN PREVIOUSLY TREATED GROWTH HORMONE DEFICIENT CHILDREN

    Thrirty-four previously growth hormone treated persons aged 17 to 35 years, diagnosed in childhood as growth hormone deficient with insulin hypoglycaemia and growth hormone peak concentrations <7 ng/ml, were r...

    S A Pedersen, J O Jørgensen, J S Christiansen, H Ørskov… in Pediatric Research (1988)

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  5. Article

    THE METABOLIC CLEARANCE RATE, APPARENT DISTRIBUTION SPACE AND PLASMA HALF-LIFE OF UNLABELLEO BIOSYNTHETIC HUMAN GROWTH HORMONE IN HYPOPITUITARY PATIENTS

    Previously published information on GH metabolism in GH-deficient patients is scarce and data are conflicting. We studied the metabolic clearance rate (MCR), plasma half-life (T1/2) and apparent distribution spac...

    T Lauritzen, Jol Jørgensen, A Flyvbjerg, Js Christiansen, H ørskov… in Pediatric Research (1988)

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  6. Article

    EVIDENCE OF LOCAL DEGRADATION OF SUBCUTANEOUSLY INJECTED BIOSYNTHETIC HUMAN GROWTH HORMONE IN HYPOPITUITARY PATIENTS

    In a previous study we observed that subcutaneously (s.c.) injected human growth hormone (hGH) resulted in significantly lower serum growth hormone profiles (AUC) than after intramusculary (i.m.) administratio...

    Jol Jørgensen, Js Christiansen, A Flyvbjerg, T Lauritzen, H Ørskov… in Pediatric Research (1988)

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  7. Article

    Absorption of human growth hormone injected subcutaneously and intramuscularly in growth deficient dwarfs

    Hunan growth hormone (HGH) is commonly administrated by i.m. injections. The high purity of the present HGH preparations makes s.c. administration an attractive alternative enabling self-administration. In thi...

    J Sandahl Christiansen, K W Kastrup, H Ørskov, C Binder in Pediatric Research (1981)

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