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Article
Targeted MRI-guided prostate biopsy: are two biopsy cores per MRI-lesion required?
This study evaluates the feasibility of performing less than two core biopsies per MRI-lesion when performing targeted MR-guided in-bore prostate biopsy.
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Article
Neuroendokrine Neoplasien der Mamma
Neuroendokrine Neoplasien (NEN) der Mamma sind spezifische Tumorentitäten. Ihre Häufigkeit wird in der Literatur mit bis zu 5 % der malignen epithelialen Neoplasien der Mamma angegeben. Definiert sind NEN der ...
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Article
Erweiterter RAS-Mutationsstatus
Die wichtigsten, für das metastasierte kolorektale Karzinom (mKRK) bislang zugelassenen zielgerichteten Substanzen sind Cetuximab (Erbitux®) und Panitumumab (Vectibix®), beides Antikörper gegen den „epidermal ...
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Article
Neuroendokrine Neoplasien des distalen Jejunums und Ileums
Neuroendokrine Neoplasien (NEN) des distalen Jejunums und Ileums leiten sich von den serotoninproduzierenden enterochromaffinen Zellen (EC-Zellen) ab. Aufgrund ihrer niedrigen proliferativen Aktivität und ihre...
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Article
Interobserver reproducibility of Gleason grading: evaluation using prostate cancer tissue microarrays
Due to PSA screening and increased awareness, prostate cancer (PCa) is identified earlier resulting in smaller diagnostic samples on prostate needle biopsy. Because Gleason grading plays a critical role in tre...
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Article
Microsatellite instability in Ewing tumor is not associated with loss of mismatch repair protein expression
Only few clinical factors predict the prognosis of patients with Ewing tumors. Unfavorable outcome is associated with primary metastatic disease, age > 15 years, tumor volume above 200 ml, and the histological...
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Article
Open AccessPrognostic relevance of Tiam1 protein expression in prostate carcinomas
The Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet....
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Chapter and Conference Paper
TRAIL-β und TRAIL-γ: Zwei neue alternative Spleißvarianten des humanen TNF-related apoptosis inducing ligand und erste Hinweise für deren Bedeutung in der Tumorbiologie des Magenkarzinoms
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Article
Open AccessDisturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas
Dysregulation of apoptosis plays an important role in tumour progression and resistance to chemotherapy. The X-linked inhibitor of apoptosis (XIAP) is considered to be the most potent caspase inhibitor of all ...
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Article
Frequency and quantity of the parvovirus B19 genome in endomyocardial biopsies from patients with suspected myocarditis or idiopathic left ventricular dysfunction
n Zusammenfassung Parvovirus B19 (PB19) gilt als Erreger der Myokarditis und als möglicher Auslöser einer Herzinsuffizienz im Kindes- und Erwachsenenalter. In der vorliegenden Studie wurde mittels quantitative...
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Article
Erstmanifestation eines Morbus Wegener an der Haut
Wir präsentieren den Fall eines 51-jährigen Patienten, bei dem sich ein Morbus Wegener zuerst an der Haut manifestierte und erst später eine Mitbeteiligung des Respirationstraktes festgestellt wurde. Anhand hi...
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Article
Open AccessApoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavage
TNF-related apoptosis-inducing ligand (TRAIL APO-2L) is a member of the TNF family and induces apoptosis in cancer cells without affecting most non-neoplastic cells. The present investigation is focused on apo...
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Article
Open AccessTRAIL-β and TRAIL-γ: two novel splice variants of the human TNF-related apoptosis-inducing ligand (TRAIL) without apoptotic potential
Tumour necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL/APO2L) is a recently identified member of the TNF family, which induces programmed cell death in a variety of neoplastic cell types, but no...
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Article
Fabry disease in patients with hypertrophic cardiomyopathy (HCM)
Morbus Fabry ist eine x-chromosomale rezessiv vererbte lysosomale Speicherkrankheit mit variablem Phänotyp. Aufgrund eines Mangels von alpha-Galaktosidase A kommt es zu einer Akkumulation von Glykosphingolipi...
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Article
Differential subcellular localization of functionally divergent survivin splice variants
Survivin is an inhibitor of apoptosis protein (IAP) that is markedly overexpressed in most cancers. We identified two novel functionally divergent splice variants, i.e. non-antiapoptotic survivin-2B and antiap...
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Article
Open AccessExpression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression
Survivin is a novel member of the inhibitor of apoptosis family and determines the susceptibility of tumour cells to pro-apoptotic stimuli. Recently, we identified two novel alternative splice variants of surv...
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Article
Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan
TRAIL (APO-2L) is a newly identified member of the TNF family and induces apoptosis in cancer cells without affecting most non-neoplastic cells, both in vitro and in vivo. Our study focused on the expression and ...
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Article
Novel survivin-related members of the inhibitor of apoptosis (IAP) family
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Article
Open AccessDeficient activation of CD95 (APO-1/ Fas)-mediated apoptosis: a potential factor of multidrug resistance in human renal cell carcinoma
The pronounced resistance of human renal cell carcinoma (RCC) to anticancer-induced apoptosis has primarily been related to the expression of P-glycoprotein and effective drug detoxification mechanisms. Becaus...
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Article
Open AccessProtein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression
The role of protein kinase C (PKC) in in vitro invasiveness of four different human renal cell carcinoma (RCC) cell lines of the clear cell type was investigated. Different PKC-inhibitors markedly inhibited in...
