Skip to main content

3 Result(s)

within Molecular Medicine Remove this filter H Piersma Remove this filter

and

  1. Article

    Open Access

    Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene

    5-fluorouracil pharmacokinetics, dihydropyrimidine dehydrogenase-activity and DNA sequence analysis were compared between a patient with extreme 5-fluorouracil induced toxicity and six control patients with no...

    J G Maring, A B P van Kuilenburg, J Haasjes, H Piersma… in British Journal of Cancer (2002)

    Download PDF (132 KB) View Article

  2. Article

    Open Access

    Feasibility of a dose-intensive CMF regimen with granulocyte colony-stimulating factor as adjuvant therapy in premenopausal patients with node-positive breast cancer

    Our aim was to study the feasibility of an intensified intravenous CMF (cyclophosphamide, methotrexate and 5-fluorouracil) schedule with the aim to escalate dose intensity (DI). Twenty-three premenopausal brea...

    A M E Bos, H de Graaf, E G E de Vries, H Piersma… in British Journal of Cancer (2000)

    Download PDF (247 KB)

  3. No Access

    Article

    Paclitaxel, ifosfamide and cisplatin with granulocyte colony-stimulating factor or recombinant human interleukin 3 and granulocyte colony-stimulating factor in ovarian cancer: a feasibility study

    The tolerability and efficacy of four courses of paclitaxel and ifosfamide plus cisplatin every 3 weeks was evaluated in patients with residual or refractory ovarian cancer. Additionally, supportive haematolog...

    GJ Veldhuis, PHB Willemse, JH Beijnen, H Boonstra, H Piersma… in British Journal of Cancer (1997)