14 Result(s)

Article

Inhibition of endogenous SHIP2 ameliorates insulin resistance caused by chronic insulin treatment in 3T3-L1 adipocytes

SHIP2 is a physiologically important negative regulator of insulin signalling hydrolysing the PI3-kinase product, PI(3,4,5)P3, which also has an impact on insulin resistance. In the present study, we examined ...

T. Sasaoka, K. Fukui, T. Wada, S. Murakami, J. Kawahara, H. Ishihara… in Diabetologia (2005)

Article

40^th EASD Annual Meeting of the European Association for the Study of Diabetes

M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

Article

Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets

Glutamate dehydrogenase (GDH) is a mitochondrial enzyme playing a key role in the control of insulin secretion. However, it is not known whether GDH expression levels in beta cells are rate-limiting for the se...

S. Carobbio, H. Ishihara, S. Fernandez-Pascual, C. Bartley… in Diabetologia (2004)

Article

SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes

PI(3,4,5)P3 produced by PI3-kinase seems to be a key mediator for insulin's metabolic actions. We have recently cloned rat SHIP2 cDNA which is abundantly expressed in target tissues of insulin. Here, we clari...

T. Sasaoka, H. Hori, T. Wada, M. Ishiki, T. Haruta, H. Ishihara… in Diabetologia (2001)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)

Article

Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets

Glucose-stimulated insulin secretion is impaired in GK (Goto-Kakizaki) rats, perhaps because of abnormalities in glucose metabolism in pancreatic islet beta cells. The glycerol phosphate shuttle plays a major...

K. Ueda, Y. Tanizawa, H. Ishihara, N. Kizuki, Y. Ohta, A. Matsutani, Y. Oka in Diabetologia (1998)

Article

Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet

JTT-501 is an insulin-sensitising compound with an isoxazolidinedione rather than a thiazolidionedione structure. Sprague-Dawley rats fed a high fat diet for 2 weeks were used as an animal model of insulin re...

J. Terasaki, M. Anai, M. Funaki, T. Shibata, K. Inukai, T. Ogihara… in Diabetologia (1998)

Article

Repetitive mitochondrial Ca2+ signals synchronize with cytosolic Ca2+ oscillations in the pancreatic beta-cell line, MIN6

We examined the relationship between cytosolic Ca²⁺ concentration ([Ca²⁺]_c) and mitochondrial matrix Ca²⁺ concentration ([Ca²⁺]_m) in the pancreatic beta-cell line, MIN6. [Ca²⁺]_c was monitored in a single or a gr...

M. Nakazaki, H. Ishihara, M. Kakei, K. Inukai, T. Asano, J.-I. Miyazaki… in Diabetologia (1998)

Article

Prediction of the surgical outcome for the treatment of cervical myelopathy by using hyperbaric oxygen therapy

The effectiveness of hyperbaric oxygen therapy (HBO) in predicting the recovery after surgery in patients with cervical compression myelopathy was evaluated. HBO has been used to treat brain and spinal cord di...

H Ishihara, H Matsui, H Kitagawa, T Yonezawa, H Tsuji in Spinal Cord (1997)

Article

Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity

Saturated fatty acids cause insulin resistance but the underlying molecular mechanism is still unknown. We examined the effect of saturated non-esterified fatty acids on insulin binding and action in transfec...

I. Usui, Y. Takata, T. Imamura, H. Morioka, T. Sasaoka, T. Sawa… in Diabetologia (1997)

Article

Mitochondrial diabetes mellitus: Prevalence and clinical characterization of diabetes due to mitochondrial tRNA^LeU(UUR) gene mutation in Japanese patients

Mutations in the mitochondrial gene were recently identified in a large pedigree of diabetes mellitus and deafness. As the mitochondrial gene is maternally inherited, Japanese diabetic patients whose mothers w...

H. Katagiri, I. Asano, H. Ishihara, K. Inukai, M. Anai, Y. Yazaki, Y. Oka… in Diabetologia (1994)

Article

Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets

Glucose-stimulated insulin secretion, glucose transport, glucose phosphorylation and glucose utilization have been characterized in the insulinoma cell line MIN6, which is derived from a transgenic mouse expre...

H. Ishihara, T. Asano, K. Tsukuda, H. Katagiri, K. Inukai, M. Anai… in Diabetologia (1993)

Article

Altered expression of glucose transporter isoforms with aging in rats — selective decrease in GluT4 in the fat tissue and skeletal muscle

To elucidate the cellular mechanisms of glucose intolerance associated with aging, both the protein and mRNA levels of glucose transporter isoforms were studied in the various tissues of young (7-week-old) and...

J. -L. Lin, T. Asano, Y. Shibasaki, K. Tsukuda, H. Katagiri, H. Ishihara… in Diabetologia (1991)