166 Result(s)

Article

The marine-derived HIF-1α inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes

Prostate cancer (PCa) ranks as the second most prevalent cancer in men, with advanced stages posing significant treatment challenges. Given its solid tumor nature, PCa is highly susceptible to hypoxia, a condi...

Siyong Peng, Yingbo Guo, Marie Irondelle… in Cellular & Molecular Biology Letters (2024)

Article

APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and apolipoprotein E (APOE) genotypes (APOE2, APOE3, and APOE4) show different AD susceptibility. Previous studies indicated that individuals...

Zhiyuan Ning, Ying Liu, Mengyao Wan, You Zuo… in Cellular & Molecular Biology Letters (2024)

Article

Acetylation modification in the regulation of macroautophagy

Macroautophagy, commonly referred to as autophagy, is an evolutionarily conserved cellular process that plays a crucial role in maintaining cellular homeostasis. It orchestrates the delivery of dysfunctional o...

Li Huang, Hongwei Guo in Advanced Biotechnology (2024)

Article

MiR-1a-3p Inhibits Apoptosis in Fluoride-exposed LS8 Cells by Targeting Map3k1

Dental fluorosis is a common chemical disease. It is currently unclear how fluorosis occurs at the molecular level. We used miRNA-seq to look at the differences between miRNAs in the cell line of ameloblasts L...

Ting Chen, Yu Gu, Guo-Hui Bai, **a Liu, Bin Chen… in Biological Trace Element Research (2024)

Article

Analysis of the components of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function

Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) is a peptide antigen released from the mycobacterial cytoplasm into the supernatant of Mycobacterium tuberculosis (Mtb) attenuated H37Ra strain after au...

**g Wei, Fangzheng Guo, Yamin Song, Tong Feng… in Cellular & Molecular Biology Letters (2024)

Article

Map** and characterization of rust resistance genes Lr53 and Yr35 introgressed from Aegilops species

The rust resistance genes Lr53 and Yr35 were introgressed into bread wheat from Aegilops longissima or Aegilops sharonensis or their S-genome containing species and mapped to the telomeric region of chromosome ar...

Binyang Xu, Tao Shen, Hong Chen, Hongna Li… in Theoretical and Applied Genetics (2024)

Article

Deciphering the impact of circRNA-mediated autophagy on tumor therapeutic resistance: a novel perspective

Cancer therapeutic resistance remains a significant challenge in the pursuit of effective treatment strategies. Circular RNAs (circRNAs), a class of non-coding RNAs, have recently emerged as key regulators of ...

Ting Wang, Mengjie He, Xudong Zhang, Zhixun Guo… in Cellular & Molecular Biology Letters (2024)

Article

Identification of superior and rare haplotypes to optimize branch number in soybean

Using the integrated approach in the present study, we identified eleven significant SNPs, seven stable QTLs and 20 candidate genes associated with branch number in soybean.

Hui Yu, Javaid Akhter Bhat, Candong Li, Beifang Zhao… in Theoretical and Applied Genetics (2024)

Article

Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation

Cervical cancer (CC) is one of the severe cancers that pose a threat to women’s health and result in death. CENPF, the centromere protein F, plays a crucial role in mitosis by regulating numerous cellular proc...

**n hui Tang, Tian nan Zhao, Li Guo, **n yue Liu… in Cell Biochemistry and Biophysics (2024)

Article

Decoding epitranscriptomic regulation of viral infection: map** of RNA N⁶-methyladenosine by advanced sequencing technologies

Elucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount for understanding pathogenic mechanisms and identifying potential therapeutic targets. T...

**angdong Fan, Yitong Zhang, Ruiying Guo, Kuo Yue… in Cellular & Molecular Biology Letters (2024)

Article

The Functional Study of Response Regulator ArlR Mutants in Staphylococcus Aureus

Staphylococcus aureus is a major cause of hospital-associated infections worldwide. The organism’s ability to form biofilms has led to resistance against current treatment options such as beta-lactams, glycopept...

**hong Zhou, Moath Refat, Yucheng Guo… in Applied Biochemistry and Biotechnology (2024)

Article

Correction: Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons

Shiji Liao, Guirong Qiu, Yan** Hu, Bohong Guo, Yuqin Qiu in AAPS PharmSciTech (2024)

Article

Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC–MS and LC–MS

Untargeted metabolomics can be used to expand our understanding of the pathogenesis of sarcopenia. However, the metabolic signatures of sarcopenia patients have not been thoroughly investigated. Herein, we exp...

Peipei Han, Chunhua Yuan, **aoyu Chen, Yuanqing Hu, **aodan Hu… in Skeletal Muscle (2024)

Article

Dietary Copper Intake and Risk of Parkinson’s Disease: a Cross-sectional Study

Copper is an essential trace element for the human body. The epidemiological evidence for the association of dietary intake of copper with the risk of Parkinson’s disease (PD) is limited. We conducted an evalu...

Zhaohao Zeng, Yanmei Cen, Lijiao **ong, Guo Hong… in Biological Trace Element Research (2024)

Article

Genome-wide association map** for seedling and adult resistance to powdery mildew in barley

Two new major QTL were identified for powdery mildew resistance. We confirmed that the QTL on 7HS contributed mainly to the adult-plant resistance, while another one on chromosome arm 1HS made a significant co...

Jie Guo, Chenchen Zhao, Sanjiv Gupta, Greg Platz… in Theoretical and Applied Genetics (2024)

Article

Ubiquitous protein lactylation in health and diseases

For decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important roles in cellular metabolism...

Junyong Wang, Ziyi Wang, Qixu Wang, … in Cellular & Molecular Biology Letters (2024)

Article

IDH1/MDH1 deacetylation promotes acute liver failure by regulating NETosis

Acute liver failure (ALF) is a life-threatening disease, but its pathogenesis is not fully understood. NETosis is a novel mode of cell death. Although the formation of neutrophil extracellular traps (NETs) has...

Yukun Wang, Chunxia Shi, ** Guo, Danmei Zhang… in Cellular & Molecular Biology Letters (2024)

Article

Correction to: Protective Efect of Manganese on Apoptosis and Mitochondrial Function of Heat-Stressed Primary Chick Embryonic Myocardial Cells

Rui Wang, Zhaoguo Shi, **lu Li, Defu Tang… in Biological Trace Element Research (2024)

Article

Thyroglobulin as a Sensitive Biomarker of Iodine Status in Mildly and Moderately Iodine-Deficient Pregnant Women

Pregnant women are more susceptible to iodine deficiency. However, there are limitations in existing indicators for the evaluation of iodine nutrition in pregnant women. The study aimed to explore whether thyr...

Yujie Jiang, Simeng Gu, Zhe Mo, Xueqing Li… in Biological Trace Element Research (2023)

Article

SIRT3 Regulates the ROS-FPR1/HIF-1α Axis under Hypoxic Conditions to Influence Lung Cancer Progression

Hypoxia-inducible factor (HIF-1α) is a therapeutic target in lung cancer, and the deacetylase sirtuin 3 (SIRT3) is closely associated with tumorigenesis. Formyl peptide receptor 1 (FPR1) is involved in a wide ...

Bo Huang, Jie Ding, HongRong Guo, HongJuan Wang… in Cell Biochemistry and Biophysics (2023)