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Article
Open AccessRegulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis
The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and disease pathogenesis. However, the contribution of AS in pancreat...
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Article
Open AccessMulti-UAV pursuit-evasion gaming based on PSO-M3DDPG schemes
The sample data for reinforcement learning algorithms often exhibit sparsity and instability, making the training results susceptible to falling into local optima. Mini-Max-Multi-agent Deep Deterministic Polic...
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Article
Cloning and expression analysis of Aerenchyma development related ShRBOH1 gene in Saussurea inversa Raab-Straube
Saussurea inversa Raab-Straube is a typical alpine plant with well-developed aerenchyma, which is its most representative structural feature. Studying the formation and development of aerenchyma in S. inversa is ...
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Article
Combining TDLAS and multi-fusion algorithms for methane gas concentration detection
High-precision methane gas detection is of great importance in industrial safety, energy production and environmental protection, etc. However, in the existing measurement techniques, the methane gas concentra...
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Article
Research on Blasting Damage Control of 90° Slit Charge Structure
This study investigates the directional blasting of a 90° slit charge structure using laboratory experiments and field tests. A 90° slit charge suitable for the corner of roadway is proposed. After the slit ch...
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Article
Field-free switching of perpendicular magnetization by two-dimensional PtTe2/WTe2 van der Waals heterostructures with high spin Hall conductivity
The key challenge of spin–orbit torque applications lies in exploring an excellent spin source capable of generating out-of-plane spins while exhibiting high spin Hall conductivity. Here we combine PtTe2 for high...
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Article
Open AccessHydrogen peroxide serves as pivotal fountainhead for aerosol aqueous sulfate formation from a global perspective
Traditional atmospheric chemistry posits that sulfur dioxide (SO2) can be oxidized to sulfate (SO42–) through aqueous-phase reactions in clouds and gas-phase oxidation. Despite adequate knowledge of traditional m...
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Article
Open AccessInsights into the potential dual-antibacterial mechanism of Kelisha capsule on Escherichia coli
Traditional Chinese medicine (TCM), AYURVEDA and Indian medicine are essential in disease prevention and treatment. Kelisha capsule (KLSC), a TCM formula listed in the Chinese Pharmacopoeia, has been clinically p...
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Article
Open AccessCellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion
Diabetic retinopathy (DR) is a major cause of blindness and is characterized by dysfunction of the retinal microvasculature. Neutrophil stasis, resulting in retinal inflammation and the occlusion of retinal mi...
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Article
Correction to: Estimation of evapotranspiration through an improved daily global solar radiation in SEBAL model: a case study of the middle Heihe River Basin
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Article
Biophysical-driven piezoelectric and aligned nanofibrous scaffold promotes bone regeneration by re-establishing physiological electrical microenvironment
The initial healing stages of bone fracture is a complex physiological process involving a series of spatially and temporally overlap** events, including pathogen clearance, immunological modulation, and ost...
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Article
Open AccessContinuous and low-carbon production of biomass flash graphene
Flash Joule heating (FJH) is an emerging and profitable technology for converting inexhaustible biomass into flash graphene (FG). However, it is challenging to produce biomass FG continuously due to the lack o...
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Article
Open AccessA novel DCTN1 mutation causing perry syndrome leads to abnormal splicing of mRNA: genetic and functional analyses
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Article
Estimation of evapotranspiration through an improved daily global solar radiation in SEBAL model: a case study of the middle Heihe River Basin
Evapotranspiration (ET) is a major factor in the water cycle that is most directly affected by land use and climate change. The accurate estimation of the daily ET is an important link in the study of its hydr...
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Article
Structure-Guided Evolution Modulate Alcohol Oxidase to Improve Ethanol Oxidation Performance
A high ethanol usage of alcohol oxidase (AOX) was required in industry. In this study, a “expand substrate pocket” strategy achieved a high activity AOX from Hansenula polymorpha (H. polymorpha) by Phe to Val res...
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Article
Constraint information extraction for 3D geological modelling using a span-based joint entity and relation extraction model
Data sparsity has long been a problem in 3D geological modeling work. The geometric, topological, and attribute information of geological bodies in geological reports provide important constraint information d...
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Article
Open AccessGraphene Oxide Treated by Temperature with Enhancement of Adsorption for Organic Pollutants and Catalytic Degradation with Hydrogen Peroxide
Graphene oxide (GO) has been used in the range of organic pollutants adsorption and degradation. It’s important to improve the performance of GO in the treatment of organic pollutants. Here, we found that the ...
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Article
Visible-light Excited and Highly Photostable Organic Fluorophore with dual-state Emission
Organic fluorophores with dual-state emission (DSE) are rare or difficult to observe because most of them display either aggregation-induced emission (AIE) or aggregation-caused quenching (ACQ). Amazing works ...
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Article
Investigating the role of smart technologies, financial, and environmental innovations in tackling the ecological sustainability: a global pathway toward low carbon energy transition
Since the beginning of the twenty-first century, the rapid development of modern technologies has brought unprecedented social prosperity to mankind as technologies penetrate every sector of the economy. These...
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Article
Allicin Overcomes Doxorubicin Resistance of Breast Cancer Cells by Targeting the Nrf2 Pathway
Breast cancer (BC) is a lethal disorder that threatens the life safety of the majority of females globally, with rising morbidity and mortality year by year. Doxorubicin is a cytotoxic anthracycline antibiotic...
