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29 Result(s)
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Giuseppe Del Giudice
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Article
Reduced antibody response to the repetitive sequence of the Plasmodium falciparum circumsporozoite protein in mice infected with Plasmodium yoelii blood forms
The immunogenicity of the carrier-free synthetic peptide, (NANP)40, from the repetitive region of the Plasmodium falciparum circumsporozoite (CS) protein was investigated in genetically responder mice (C57BL/6, H...
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Article
Open AccessChallenges for vaccination in the elderly
The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly peo...
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Book
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Chapter
Introduction
We have been living with influenza as long as history can remember, and we are so used to the fact that this disease is part of life that we usually do not pay much attention to it. Even the science of influen...
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Chapter
Waiting for a pandemic
After a quiet period of nearly 30 years, influenza strains with hemagglutinin types that have not been seen in humans previously started to jump from birds to man, suggesting the risk of a new influenza pandem...
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Chapter and Conference Paper
Vortex Shaft Outlet
Vortex drop shafts are widely used in practice to connect sewer mains characterized by large elevation difference. These structures conventionally include three key elements: intake structure, vertical shaft a...
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Chapter and Conference Paper
Vortex Drop Shaft for Supercritical Flow
Vortex drop shafts are used in urban drainage systems to connect two sewers located at considerably different elevations by means of a vertical conduit. The vortex drop shaft was first designed by Drioli (1947...
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Protocol
Determining the Activity of Mucosal Adjuvants
Mucosal vaccination offers the advantage of blocking pathogens at the portal of entry, improving patient’s compliance, facilitating vaccine delivery, and decreasing the risk of unwanted spread of infectious ag...
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Book
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Chapter
Learning from the First Pandemic of the Twenty-First Century
The response to the first influenza pandemic of the twenty-first century was facilitated by years of preparation for a possible pandemic caused by the avian influenza H5N1. The threat of an H5N1 pandemic had l...
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Chapter
Novel Strategies for Improved Vaccines for the Elderly: The Example of Influenza
Aging is characterized by a panoply of defects in various compartments of the immune system which render elderly individuals more susceptible to infectious diseases, and can profoundly affect the immunogenicit...
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Article
Energy Production in Water Distribution Networks: A PAT Design Strategy
Pump operating as turbine (PAT) is an effective source of reducing the equipment cost in small hydropower plants. However, the manufacturers provide poor information on the PAT performance thus representing a ...
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Article
Open AccessExpression of the Streptococcus pneumoniae pilus-1 undergoes on and off switching during colonization in mice
Streptococcus pneumoniae pili contribute to adherence and virulence. The regulation of pilus-1 expression is bistable, thus piliated strains contain a variable proportion of pilus-1-non-expressing bacteria. We in...
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Article
Preliminary Estimate of Detention Basin Efficiency at Watershed Scale
Urban encroachment in natural floodplain areas and infrastructures interfering with watercourses have caused higher flood risks in lowland areas. In this context, detention basins have become a fundamental ins...
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Article
Combined Effects of Parallel and Series Detention Basins for Flood Peak Reduction
A simple analytical method is proposed that allows a preliminary evaluation of the overall efficiency of a detention basin system for flood risk reduction in a specific target section. Solutions are provided b...
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Chapter
Inactivated and Adjuvanted Influenza Vaccines
Inactivated influenza vaccines are produced every year to fight against the seasonal epidemics of influenza. Despite the nonoptimal coverage, even in subjects at risk like the elderly, pregnant women, etc., th...
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Article
Open AccessSensitivity Analysis and Calibration of a Rainfall-Runoff Model with the Combined Use of EPA-SWMM and Genetic Algorithm
An integrated Visual Basic Application interface is described that allows for sensitivity analysis, calibration and routing of hydraulichydrological models. The routine consists in the combination of three fre...
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Article
Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain
Antibodies elicited by vaccination with influenza vaccine produced in eggs bind more strongly to the egg-adapted vaccine strain than to wild-type circulating strains.
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Article
Open AccessFighting against a protean enemy: immunosenescence, vaccines, and healthy aging
The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect...
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Article
Open AccessVaccination programs for older adults in an era of demographic change
Populations are aging worldwide. This paper summarizes some of the challenges and opportunities due to the increasing burden of infectious diseases in an aging population.
