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  1. Article

    Managing perioperative myocardial injury

    Michelle S. Chew, Christian Puelacher, Giovanna Lurati-Buse in Intensive Care Medicine (2024)

  2. Article

    Open Access

    Possible effect of the early administration of tranexamic acid on myocardial injury in patients with severe trauma

    Hemodynamic stabilization plays a crucial role in the treatment of patients suffering from severe trauma. Current guidelines recommend the early administration of tranexamic acid (TXA) for bleeding control. Wh...

    Alexandra Stroda, Simon Thelen, René M’Pembele in Journal of Thrombosis and Thrombolysis (2024)

  3. Article

    Open Access

    Association between hypotension and myocardial injury in patients with severe trauma

    During resuscitation of patients with severe trauma, guidelines recommend permissive hypotension prior to surgical bleeding control. However, hypotension may be associated with reduced organ perfusion and mult...

    Alexandra Stroda, Simon Thelen in European Journal of Trauma and Emergency S… (2023)

  4. Article

    Open Access

    Postoperative high-sensitivity troponin T predicts 1-year mortality and days alive and out of hospital after orthotopic heart transplantation

    Orthotopic heart transplantation (HTX) is the gold standard to treat end-stage heart failure. Numerous risk stratification tools have been developed in the past years. However, their clinical utility is limite...

    René M’Pembele, Sebastian Roth, Anthony Nucaro in European Journal of Medical Research (2023)

  5. Article

    Open Access

    Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation

    The number of patients waiting for heart transplantation (HTX) is increasing. Thus, identification of outcome-relevant factors is crucial. This study aimed to identify perioperative factors associated with day...

    René M’Pembele, Sebastian Roth, Alexandra Stroda, Tilman Reier in Scientific Reports (2022)

  6. Article

    Open Access

    Incidence and prognosis of myocardial injury in patients with severe trauma

    Severe trauma can lead to end organ damages of varying severity, including myocardial injury. In the non-cardiac surgery setting, there is extensive evidence that perioperative myocardial injury is associated ...

    Alexandra Stroda, Simon Thelen in European Journal of Trauma and Emergency S… (2022)

  7. Article

    Open Access

    Evaluation of clinical outcomes in patients treated with heparin or direct thrombin inhibitors during extracorporeal membrane oxygenation: a systematic review and meta-analysis

    The number of patients treated with extracorporeal membrane oxygenation (ECMO) devices is increasing. Anticoagulation therapy is crucial to prevent thrombosis during ECMO therapy. Predominantly, heparin has be...

    René M’Pembele, Sebastian Roth, Aljoscha Metzger, Anthony Nucaro in Thrombosis Journal (2022)

  8. Article

    Open Access

    Cardiovascular imaging following perioperative myocardial infarction/injury

    Patients develo** perioperative myocardial infarction/injury (PMI) have a high mortality. PMI work-up and therapy remain poorly defined. This prospective multicenter study included high-risk patients undergo...

    Ketina Arslani, Danielle M. Gualandro, Christian Puelacher in Scientific Reports (2022)

  9. Article

    Open Access

    Neutrophil-lymphoycyte-ratio, platelet-lymphocyte-ratio and procalcitonin for early assessment of prognosis in patients undergoing VA-ECMO

    The use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasing, but mortality remains high. Early assessment of prognosis is challenging and valid markers are lacking. This study aimed to...

    Sebastian Roth, René M’Pembele, Alexandra Stroda, Catrin Jansen in Scientific Reports (2022)

  10. Article

    Open Access

    Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I

     Perioperative myocardial infarction/injury (PMI) diagnosed by high-sensitivity troponin (hs-cTn) T is frequent and a prognostically important complication of non-cardiac surgery. We aimed to evaluate the inci...

    Danielle M. Gualandro, Christian Puelacher in Clinical Research in Cardiology (2021)

  11. Article

    Open Access

    Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO

    Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supports patients suffering from refractory cardiogenic shock. Thromboembolic complications (TeC) are common in VA-ECMO patients and are associated w...

    Sebastian Roth, Catrin Jansen, René M’Pembele, Alexandra Stroda in Scientific Reports (2021)

  12. No Access

    Article

    Obesity paradox and perioperative myocardial infarction/injury in non-cardiac surgery

    The impact of obesity on the incidence of perioperative myocardial infarction/injury (PMI) and mortality following non-cardiac surgery is not well understood.

    Reka Hidvegi, Christian Puelacher, Danielle M. Gualandro in Clinical Research in Cardiology (2020)