25 Result(s)

Article

Racial disparities in survival outcomes among breast cancer patients by molecular subtypes

Differences in tumor biology, genomic architecture, and health care delivery patterns contribute to the breast cancer mortality gap between White and Black patients in the US. Although this gap has been well d...

Fangyuan Zhao, Brenda Copley, Qun Niu, Fang Liu… in Breast Cancer Research and Treatment (2021)

Article

Clinical evaluation of germline polymorphisms associated with capecitabine toxicity in breast cancer: TBCRC-015

Capecitabine is important in breast cancer treatment but causes diarrhea and hand-foot syndrome (HFS), affecting adherence and quality of life. We sought to identify pharmacogenomic predictors of capecitabine ...

Peter H. O’Donnell, Vassily Trubetskoy… in Breast Cancer Research and Treatment (2020)

Article

Treatment-induced symptoms, depression and age as predictors of sexual problems in premenopausal women with early breast cancer receiving adjuvant endocrine therapy

Sexual dysfunction is an important concern of premenopausal women with early breast cancer. We investigated predictors of sexual problems in two randomized controlled trials.

Karin Ribi, Weixiu Luo, Barbara A. Walley… in Breast Cancer Research and Treatment (2020)

Article

A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors

Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor. Metformin may potentiate mTOR inhibition by sirolimus while mitigating its adverse effects. We conducted a pilot study to test this hypothesis.

Amikar Sehdev, Theodore Karrison, Yuanyuan Zha… in Cancer Chemotherapy and Pharmacology (2018)

Article

Adjuvant Endocrine Therapy for Hormone Receptor-Positive Early Breast Cancer in Premenopausal Patient: Understanding the Data

Breast cancer diagnosed at a young age is associated with a poor prognosis. It is possible that inadequate endocrine therapy for the youngest women contributes to their poorer prognosis. Data on optimal endocr...

Poornima Saha, Gini F. Fleming in Current Breast Cancer Reports (2015)

Article

Predictive value and clinical utility of centrally assessed ER, PgR, and Ki-67 to select adjuvant endocrine therapy for premenopausal women with hormone receptor-positive, HER2-negative early breast cancer: TEXT and SOFT trials

The SOFT and TEXT randomized phase III trials investigated adjuvant endocrine therapies for premenopausal women with hormone receptor-positive (HR+) early breast cancer. We investigated the prognostic and pre...

Meredith M. Regan, Olivia Pagani… in Breast Cancer Research and Treatment (2015)

Article

A phase I trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer

The mammalian target of rapamycin (mTOR) plays a critical role in promoting tumor cell growth and is frequently activated in breast cancer. In preclinical studies, the antitumor activity of mTOR inhibitors is ...

Cynthia X. Ma, Vera J. Suman, Matthew Goetz… in Breast Cancer Research and Treatment (2013)

Article

Phase II trial of temsirolimus in patients with metastatic breast cancer

Preclinical models suggested that activating mutations of the PIK3CA gene are associated with sensitivity to inhibitors of the mammalian target of rapamycin (mTOR). In breast cancers, PIK3CA mutations are associa...

Gini F. Fleming, Cynthia X. Ma, Dezheng Huo… in Breast Cancer Research and Treatment (2012)

Article

A phase II trial of trastuzumab in combination with low-dose interleukin-2 (IL-2) in patients (PTS) with metastatic breast cancer (MBC) who have previously failed trastuzumab

Trastuzumab mediates the lysis of HER2-expressing breast cancer cell lines by interleukin-2 (IL-2) primed natural killer (NK) cells. We hypothesized that IL-2 would augment the anti-tumor effects of trastuzuma...

Aruna Mani, Julie Roda, Donn Young… in Breast Cancer Research and Treatment (2009)

Chapter

Treatment of Advanced and Recurrent Carcinoma: Chemotherapy

The development of chemotherapy in endometrial cancer took place over two decades, but finally drug combinations have convincingly been shown to have a role in the treatment of advanced and recurrent endometri...

Halla Nimeiri, Gini F. Fleming in Uterine Cancer (2009)

Article

Pharmacokinetic modulation of oral etoposide by ketoconazole in patients with advanced cancer

Etoposide is a widely used cytotoxic drug that is commercially available in both intravenous and oral formulations. High interpatient pharmacokinetic variability has been associated with oral etoposide adminis...

Wei Peng Yong, Apurva A. Desai, Federico Innocenti… in Cancer Chemotherapy and Pharmacology (2007)

Article

A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer

Carboxyamidotriazole (CAI) is a novel antineoplastic agent in clinical development with limited oral bioavailability. In vitro, ketoconazole has been demonstrated to inhibit CYP3A4-mediated metabolism of CAI. ...

Apurva A. Desai, Federico Innocenti, Linda Janisch… in Cancer Chemotherapy and Pharmacology (2004)

Article

Pentostatin pharmacokinetics and dosing recommendations in patients with mild renal impairment

Abstract

Chetan Lathia, Gini F. Fleming, Mark Meyer… in Cancer Chemotherapy and Pharmacology (2002)

Article

Estimation of the effect of food on the disposition of oral 5-fluorouracil in combination with eniluracil

Aims: To determine the effect of food on the pharmacokinetics of 5-fluoruracil (5-FU) taken orally with eniluracil and to compare the performance of different pharmacokinetic analysis methods in the detection a p...

Dale R. Shepard, Sridhar Mani, Helen Kastrissios… in Cancer Chemotherapy and Pharmacology (2002)

Article

Expedition inspiration consensus 2001

Christopher C. Benz, Leena Hilakivi-Clarke… in Breast Cancer Research and Treatment (2001)