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  1. No Access

    Article

    Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-Making

    Entrectinib is a selective inhibitor of ROS1/TRK/ALK kinases, recently approved for oncology indications. Entrectinib is predominantly cleared by cytochrome P450 (CYP) 3A4, and modulation of CYP3A enzyme activ...

    Nassim Djebli, Vincent Buchheit… in European Journal of Drug Metabolism and Ph… (2021)

  2. No Access

    Article

    Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib

    Entrectinib is a potent and selective tyrosine kinase inhibitor (TKI) of TRKA/B/C, ROS1, and ALK with both systemic and CNS activities, which has recently received FDA approval for ROS1 fusion-positive non-sma...

    Neil Parrott, Cordula Stillhart, Marc Lindenberg, Bjoern Wagner… in The AAPS Journal (2020)