20,065 Result(s)
-
Article
Open AccessChromosome-level genome assembly of Hippophae rhamnoides variety
Fructus hippophae (Hippophae rhamnoides spp. mongolica×Hippophae rhamnoides sinensis), a hybrid variety of sea buckthorn that Hippophae rhamnoides spp. mongolica serves as the female parent and Hippophae rhamnoid...
-
Article
Open AccessSelective and stable CO2 electroreduction at high rates via control of local H2O/CO2 ratio
Controlling the concentrations of H2O and CO2 at the reaction interface is crucial for achieving efficient electrochemical CO2 reduction. However, precise control of these variables during catalysis remains chall...
-
Article
Open AccessDropBlot: single-cell western blotting of chemically fixed cancer cells
Archived patient-derived tissue specimens play a central role in understanding disease and develo** therapies. To address specificity and sensitivity shortcomings of existing single-cell resolution proteofor...
-
Article
Open AccessA strategy for tough and fatigue-resistant hydrogels via loose cross-linking and dense dehydration-induced entanglements
Outstanding overall mechanical properties are essential for the successful utilization of hydrogels in advanced applications such as human-machine interfaces and soft robotics. However, conventional hydrogels ...
-
Article
Open AccessAuthor Correction: HDAC6, modulated by miR-206, promotes endometrial cancer progression through the PTEN/AKT/mTOR pathway
-
Article
Open AccessNitrifying niche in estuaries is expanded by the plastisphere
The estuarine plastisphere, a novel ecological habitat in the Anthropocene, has garnered global concerns. Recent geochemical evidence has pointed out its potential role in influencing nitrogen biogeochemistry....
-
Article
Open AccessLoss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression
Low response rate, treatment relapse, and resistance remain key challenges for cancer treatment with immune checkpoint blockade (ICB). Here we report that loss of specific tumor suppressors (TS) induces an inf...
-
Article
Open AccessMedical intelligence using PPG signals and hybrid learning at the edge to detect fatigue in physical activities
The educational environment plays a vital role in the development of students who participate in athletic pursuits both in terms of their physical health and their ability to detect fatigue. As a result of rec...
-
Article
Open AccessLong-term prediction modeling of shallow rockburst with small dataset based on machine learning
Rockburst present substantial hazards in both deep underground construction and shallow depths, underscoring the critical need for accurate prediction methods. This study addressed this need by collecting and ...
-
Article
Open AccessOptimizing high-temperature energy storage in tungsten bronze-structured ceramics via high-entropy strategy and bandgap engineering
As a vital material utilized in energy storage capacitors, dielectric ceramics have widespread applications in high-power pulse devices. However, the development of dielectric ceramics with both high energy de...
-
Article
Open AccessCholine consumption reduces CVD risk via body composition modification
Despite extensive research on the relationship between choline and cardiovascular disease (CVD), conflicting findings have been reported. We aim to investigate the relationship between choline and CVD. Our ana...
-
Article
Open AccessEffect of Flammulina velutipes polysaccharide on mitochondrial apoptosis in lung adenocarcinoma A549 cells
FVP is a polysaccharide extracted from Flammulina velutipes with immunomodulatory, anti-tumor, and anti-oxidation activities. In this study, we obtained the crude polysaccharide FVP-C from the water extract of Fl...
-
Article
Open AccessHarnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subty**
The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is still challenging due to the lack of a capturing surface with strong target-binding affinity and non-target-ce...
-
Article
Open AccessImmune cell landscapes are associated with high-grade serous ovarian cancer survival
High-grade serous ovarian cancer (HGSOC) is an aggressive disease known to develop resistance to chemotherapy. We investigated the prognostic significance of tumor cell states and potential mechanisms underlyi...
-
Article
Open AccessMultiparametric MRI–based radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is often treated with neoadjuvant systemic therapy (NAST). We investigated if radiomic models based on multiparametric Magnetic Resonance Imaging (MRI) obtained early durin...
-
Article
Open AccessTherapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis
Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events in mucus dysfunction, we discover ...
-
Article
Open AccessAdeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade
There are numerous mechanisms by which glioblastoma cells evade immunological detection, underscoring the need for strategic combinatorial treatments to achieve appreciable therapeutic effects. However, develo...
-
Article
Open AccessDifferential potassium channel inhibitory activities of a novel thermostable degradation peptide BmKcug1a-P1 from scorpion medicinal material and its N-terminal truncated/restored peptides
Thermally stable full-length scorpion toxin peptides and partially degraded peptides with complete disulfide bond pairing are valuable natural peptide resources in traditional Chinese scorpion medicinal materi...
-
Article
Open AccessDouble closed loop PI control with full compensation arc elimination based on zero sequence voltage of neutral point
Aiming at the problem of zero sequence voltage generated by unbalance parameters of line to ground, which affects arc suppression effect of grounding fault of controllable voltage source. By analyzing the infl...
-
Article
Open AccessGermline β−1,3-glucan deposits are required for female gametogenesis in Arabidopsis thaliana
Correct regulation of intercellular communication is a fundamental requirement for cell differentiation. In Arabidopsis thaliana, the female germline differentiates from a single somatic ovule cell that becomes e...