17 Result(s)
-
Article
Open AccessSensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception
Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function...
-
Article
Open AccessRole of TMEM100 in mechanically insensitive nociceptor un-silencing
Mechanically silent nociceptors are sensory afferents that are insensitive to noxious mechanical stimuli under normal conditions but become sensitized to such stimuli during inflammation. Using RNA-sequencing ...
-
Article
Open AccessPublisher Correction: Lipidome determinants of maximal lifespan in mammals
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
-
Article
Open AccessVoltage gating of mechanosensitive PIEZO channels
Mechanosensitive PIEZO ion channels are evolutionarily conserved proteins whose presence is critical for normal physiology in multicellular organisms. Here we show that, in addition to mechanical stimuli, PIEZ...
-
Article
Open AccessCongenital deafness is associated with specific somatosensory deficits in adolescents
Hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. Here we used a battery of quantitative sensory tests to probe touch, t...
-
Article
Open AccessLipidome determinants of maximal lifespan in mammals
Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationshi...
-
Article
Open AccessFxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain
Identification of the molecular mechanisms governing sensory neuron subtype excitability is a key requisite for the development of treatments for somatic sensory disorders. Here, we show that the Na,K-ATPase m...
-
Article
Open AccessA Probabilistic Model for Estimating the Depth and Threshold Temperature of C-fiber Nociceptors
The subjective experience of thermal pain follows the detection and encoding of noxious stimuli by primary afferent neurons called nociceptors. However, nociceptor morphology has been hard to access and the me...
-
Article
Open AccessPhotoswitchable fatty acids enable optical control of TRPV1
Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incor...
-
Article
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical...
-
Article
Open AccessTuning Piezo ion channels to detect molecular-scale movements relevant for fine touch
In sensory neurons, mechanotransduction is sensitive, fast and requires mechanosensitive ion channels. Here we develop a new method to directly monitor mechanotransduction at defined regions of the cell-substr...
-
Article
A stomatin-domain protein essential for touch sensation in the mouse
The sense of touch is mediated by the many mechanoreceptors present in the skin. Now, for first time in a vertebrate, a single molecule whose function is necessary for this primary transduction event has been ...
-
Article
Correction: Corrigendum: The mammalian sodium channel BNC1 is required for normal touch sensation
Nature 407, 1007–1011 (2000). In this Letter, the x axes for the stimulus response functions shown in Fig. 2a–f were incorrectly labelled 5, 10, 20, 40 (and 80) µm. The axes should read 50, 100, 200, 400 (and ...
-
Article
The mammalian sodium channel BNC1 is required for normal touch sensation
Of the vertebrate senses, touch is the least understood at the molecular level. The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown1,2,3. However, the sim...
-
Article
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
Neuregulins and their specific receptors, members of the ErbB family of tyrosine kinases, have been implicated in the control of growth and development of Schwann cells1,2,3, specialized cells that wrap around ne...
-
Article
NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons
AFTER peripheral nerve section, sensory neurons regenerate but do not regain their original topographical position in the skin1. Here we report that in the early stages of sciatic nerve regeneration, the cutaneou...
-
Article
Requirement for nerve growth factor in the development of myelinated nociceptors in vivo
IN adult animals, sensory neurons innervating the skin are phenotypically diverse1–3. We have now investigated whether nerve growth factor (NGF) has a physiological role in the development of this diversity. We g...
