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  1. Article

    Open Access

    Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours

    An important determinant of cellular resistance to chemotherapeutic O6-alkylating agents, which comprise methylating and chloroethylating agents, is the ability of cells to repair alkylation damage at the O6-posi...

    M J Clemons, M C Bibby, H El Teraifi, G Forster, J Kelly… in British Journal of Cancer (2002)

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  2. No Access

    Article

    Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers

    A study was made of the relationship between the intrinsic radiosensitivity of human cervical tumours and the expression of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (HAP1). The radiosensi...

    CJ Herring, CML West, DP Wilks, SE Davidson, RD Hunter… in British Journal of Cancer (1998)

  3. No Access

    Article

    Prospective evaluation of cell kinetics in head and neck squamous carcinoma: the relationship to tumour factors and survival

    Tumour growth rates were measured in 105 patients using in vivo incorporation of bromodeoxyuridine (BrdU) and investigated for any relationship to tumour factors or survival. The median labelling index (LI) wa...

    LD Cooke, TG Cooke, G Forster, AS Jones, PM Stell in British Journal of Cancer (1994)

  4. No Access

    Article

    Tumour growth rates in squamous carcinoma of the head and neck measured by in vivo bromodeoxyuridine incorporation and flow cytometry

    The cell kinetics of 82 squamous cell carcinomas of the head and neck were studied by in vivo administration of the thymidine analogue, bromodeoxyuridine (BrdUrd). Ploidy, BrdUrd labelling index (LI), duration...

    G Forster, TG Cooke, LD Cooke, PD Stanton, G Bowie, PM Stell in British Journal of Cancer (1992)

  5. No Access

    Article

    Cellular DNA content and prognosis in surgically treated squamous carcinoma of the larynx

    LD Cooke, TG Cooke, G Forster, TR Helliwell, PM Stell in British Journal of Cancer (1991)

  6. No Access

    Article

    Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum

    We measured tumour cellular DNA in 102 patients entered into two phase III trials of chemotherapy for end stage squamous carcinoma of the head and neck. The median survival of untreated patients with aneuploid...

    LD Cooke, TG Cooke, F Bootz, G Forster, TR Helliwell… in British Journal of Cancer (1990)