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Article
Lung Tissue Resistance in Healthy Children
Extract: In ten healthy children, simultaneous measurements were made of the total pulmonary resistance and the airway resistance. The difference between these two measurements gave the lung tissue resistance ...
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Article
HAEMATOLOGY: PRESERVATION OF 2,3-DPG AND ATP IN CITRATED BLOOD
ATP and 2, 3-DPG have been shown to play major roles in the viablility of erythrocytes and the preservation of function of hemoglobin A.
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Article
130: Ionised calcium (Ca++), total calcium (CaTot) and immunoreactive parathyroid hormone (iPTH) and electrocardiographic changes with CPD blood before and during exchange transfusions
Ca++, CaTot, Mg, PO4 protein, pH and iPTH were measured in 16 1-6 day old hyperbilirubinemic infants before and during exchange transfusions with CPD blood. 9 of the 16 infants were supplemented with 0.11 mmoles ...
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Article
20: Map** of the High-Affinity Bilirubin-Binding Site of Human Serum Albumin
The nature of bilirubin binding to serum albumin is of considerable interest in the understanding of neonatal hyperbilirubinemia. Each albumin molecule has been shoun to contain 1 high-affinity and 2 low-affin...
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Article
Effect of Propranolol on the Erythrocyte Membrane and Mechanism of its Action on the Oxygen Affinity
Propranolol, a β-adrenergic blocker, is known to decrease the hemoglobin oxygen affinity in concentrations 5 to 10 fold the therapeutic level. Since both intraery-throcytic pH and potassium concentration decre...
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Article
Prenatal manifestation of isolated ACTH-deficiency
In a 34 yr old pregnant woman, serum(S)-HPL (3.3 ug/ml, 34 weeks)and urinary (U)-HCG (19000 IU/24 h, 28 weeks) were normal, but U-estriol (5.4, 4.5, 3.5mg/24h at 32, 33 and 34 weeks) was low without any compli...
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Article
Unmasking of the Thomsen-cryptantigen in necrotising enterocolitis (NEC): Bacteriological and immunological findings: 17
Clostridial infections have been associated with neonatal NEC. Neuraminidase, produced by Cl. perfringens and other clostridial species, cleaves neuraminic acid from the red blood cell glycoprotein and thus ex...
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Article
Energy metabolism (M) and substrate utilisation (SU) in very low birthweight infants (VLB) during the first month of life: 57
M and SU were studied using a new indirect calorimeter which fits into an incubator and allows around the clock measurements. 7 VLB (≤ 1'500 g) were kept under standard nursing conditions in a thermoneutral en...
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Article
Relationship between Energy Expenditure (EE) and Weight Gain (WG) in very low birthweight infants (VLB) auring the first weeks of life
The time course of EE was studied using an indirect calorimeter which fits into an incubator and allows around the clock measurements.In 9 VLB (1134±370g;29±3 weeks; appropriate for gest.age) V02 and VC02 were...
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Article
Globin synthesis in β-thalassemia major without anemia
Globin synthesis in β-thalassemia major without anemia. A 2½ year old girl (N.B.) with homozygous β-thalassemia (thal.) with only mild anemia (Hb 10.6-12.8 g/dl) and with complete absence of HbA, which is repl...
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Article
RELIABILITY AND SAFETY OF TRANSCUTANEOUS CARBON DIOXIDE TENSION (tcPCO2): MONITORING AT 42°C SENSOR TEMPERATURE DURING 24 HRS WITHOUT REPLACEMENT
TcPCO2 monitoring is widely used in the neonatal ICU. Reliability and safety of this indirect method to measure arterial PCO2(PaCO2) have been questioned, particularly when the sensor remains in place for more th...
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Article
90 VITAMIN E IS EXPOSED TO OXIDATION IN RED CELL MEMBRANES BUT IS PROTECTED DURING TRANSPORT IN PLASMA
α-Tocopherol (Vitamin E=E) is the only antioxidant of red cell membranes. Its oxidation prevents damage of membrane phospholipids and proteins. E is transported in plasma and delivered to cell membranes by lip...
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Article
FACTORS INFLUENCING CEREBRAL BLOOD FLOW (CBF) IN PREMATURE BABIES DURING THE FIRST WEEK AFTER BIRTH
In order to evaluate the role of CBF in the pathogenesis of periventricular haemorrhage and leukomalacia, we measured CBF with the non-invasive Xenon-133 clearance method. Intravenous application of Xenon and ...
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Article
EFFECT OF SLEEP STATE ON CEREBRAL HAEMOGLOBIN (Hb) VOLUME IN TERM NEWBORN INFANTS ASSESSED BY NEAR INFRARED SPECTROSCOPY (NIRS)
NIRS can be used for monitoring cerebral haemodynamics and oxygenation in newborn infants. The AIM of this study was to assess the difference in cerebral Hb volume (Hb-tot = Hb-ox + Hb-red) between quiet and acti...
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Article
OXYHEMOGLOBIN AFFINITY MODULATES CEREBRAL BLOOD FLOW (CBF) IN PREMATURE BABIES
Low CBF is thought to cause periventricular leukomalacia in premature babies, but a normal outcome has also been observed. Low CBF found after exchange transfusion in lambs was explained by the lower oxygen af...
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Article
A European multicenter randomized controlled trial of single dose surfactant therapy for idiopathic respiratory distress syndrome
We performed a multicenter prospective randomized controlled trial to determine the efficacy and safety of the surfactant preparation, Survanta (Abbott Laboratories, Chicago, USA), for 750–1750 g infants with ...
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Article
141 ACCELERATION OF THE SWITCH FROM FETAL TO ADULT HAEMOGLOBIN SYNTHESIS BY EXTRAUTERINE LIFE IN HUMAN NEWBORN INFANTS
Synthesis of human haemoglobin is directed by α-, β-, δ-, Glyγ- and Alaγ-genes. The switch from fetal to adult erythropoiesis includes a genetically controlled suppression of the γ- and activation of the β- and δ...
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Article
157 NEONATAL POLYCYTHEMIA: HEMODILUTION WITH SALINE VS SERUM. EFFECTS ON HEMATOCRIT, BLOOD- AND PLASMA VOLUME
We compared the effects of isovolumetric hemodilution (HD) with saline (n=8) and human serum (n=8) on venous hematocrit (Hct), plasma volume (PV, Evans Blue), blood volume (BV), and total plasma protein (TPP) ...
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Article
13 COMPARISON BETWEEN 133XENON CLEARANCE AND NEAR INFRARED SPECTROSCOPY FOR ESTIMATION OF CEREBRAL BLOOD FLOW
Estimations of cerebral blood flow (CBF) were attempted by both 133Xe clearance and near infrared spectroscopy (NIRS) on 11 occasions in 9 infants (4 girls and 5 boys). The median (range) gestational age was 27 (...
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Article
Comparison between Near Infrared Spectroscopy and 133Xenon Clearance for Estimation of Cerebral Blood Flow in Critically Ill Preterm Infants
ABSTRACT: Estimations of cerebral blood flow were performed by both near infrared spectroscopy and 133xenon clearance on 12 occasions in nine critically ill premature infants (26–29 gestational wk) who required m...