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Article
Open AccessIntegrative proteomics and metabolomics data analysis exploring the mechanism of brain injury after cardiac surgery in chronic stress rats
Preoperative chronic stress (CS) is associated with postoperative brain injury in patients undergoing open heart cardiac surgery. This research is to explore the potential molecular biological mechanisms of br...
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Article
Open AccessComprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation
Hyperthermic intraperitoneal chemotherapy’s role in ovarian cancer remains controversial, hindered by limited understanding of hyperthermia-induced tumor cellular changes. This limits develo** potent combina...
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Article
Open AccessAn update of predictive biomarkers related to WEE1 inhibition in cancer therapy
WEE1 is a crucial kinase involved in the regulation of G2/M checkpoint within the cell cycle. This article aims to comprehensively review the existing knowledge on the implication of WEE1 as a therapeutic targ...
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Article
Open AccessThe protocol of Enhanced Recovery After Cardiac Surgery (ERACS) in congenital heart disease: a stepped wedge cluster randomized trial
The Enhanced Recovery After Cardiac Surgery (ERACS) programs are comprehensive multidisciplinary interventions to improve patients’ recovery. The application of the ERAS principle in pediatric patients has not...
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Chapter and Conference Paper
Analysis of Energy Saving of Building Envelope in Hot Summer and Cold Winter Region—Take an Office Building as Example
The climatic conditions in hot summer and cold winter region are special, which is the hottest region at the same latitude except for desert areas in summer, and the coldest region at the same latitude in wint...
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Article
Digital Transformation and Over-Investment: Exploring the Role of Rational Decision-Making and Resource Surplus in the Knowledge Economy
This paper examines the impact of digital transformation on over-investment behavior among Chinese A-share listed companies in Shanghai and Shenzhen from 2016 to 2020. The study reveals that enterprise digital...
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Article
Open AccessEffect of hemoglobin and oxygen saturation on adverse outcomes in children with tetralogy of fallot: a retrospective observational study
Tetralogy of Fallot (TOF) is a common cyanotic congenital heart malformation that carries a high risk of right-to-left shunting. Anemia is characterized by decreased hemoglobin (Hb) levels that can affect tiss...
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Article
Ultrasound-guided Serratus Anterior Plane Block, Along with Improved Parasternal Block, is Superior to Serratus Anterior Plane Block Alone in Relieving Pain for Rhinoplasty with Autologous Costal Cartilage
Rhinoplasty with autologous costal cartilage (ACC) is followed by severe pain in the chest. Ultrasound-guided (USG) serratus anterior plane block (SAPB), in combination with parasternal block (PSB), was earlie...
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Article
High-efficiency CO2 sequestration through direct aqueous carbonation of carbide slag: determination of carbonation reaction and optimization of operation parameters
Under the dual-carbon target, CO2 mineralization through solid wastes presents a mutually beneficial approach for permanent carbon emission reduction at a low material cost, while also enabling the resource utili...
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Article
Evaluation of left ventricular blood flow kinetic energy in patients with hypertension by four-dimensional flow cardiovascular magnetic resonance imaging: a preliminary study
To evaluate the intra-cavity left ventricular (LV) blood flow kinetic energy (KE) parameters using four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) in patients with hypertension (HTN).
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Article
Does the increase of labor protection intensity promote regional economic growth? Evidence from China
Using inter-provincial panel data from 1998 to 2012, and taking the implementation of China's new “Labor Contract Law” in 2008 as a quasi-natural experiment, this study uses the differences-in-differences empi...
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Article
Open AccessA simple-to-use nomogram for predicting prolonged mechanical ventilation for children after Ebstein anomaly corrective surgery: a retrospective cohort study
Prolonged mechanical ventilation (PMV) after pediatric cardiac surgery imposes a great burden on patients in terms of morbidity, mortality as well as financial costs. Ebstein anomaly (EA) is a rare congenital ...
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Article
S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats
Clinical studies have found that ketamine has a rapid and lasting antidepressant effect, especially in the case of patients with major depressive disorder (MDD). The molecular mechanisms, however, remain uncle...
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Article
Influence of Ba on Co-Al-Ba composite oxide catalysts in auto-thermal reforming of acetic acid for hydrogen production
Auto-thermal reforming (ATR) of acetic acid (HAc) is one of the potential approaches to produce hydrogen. However, the current catalysts suffered from deactivation raised from sintering and carbon deposition. ...
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Chapter
An Analog of the Bickel–Rosenblatt Test for Error Density in the Linear Regression Model
This paper addresses the problem of testing the goodness-of-fit hypothesis pertaining to error density in multiple linear regression models with non-random and random predictors. The proposed tests are based o...
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Article
An analog of Bickel–Rosenblatt test for fitting an error density in the two phase linear regression model
This paper discusses a test of goodness-of-fit of a known error density in a two phase linear regression model in the case jump size at the phase transition point is fixed or tends to zero with the increasing ...
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Article
Open AccessEffects of pre-operative oral carbohydrates on insulin resistance and postoperative recovery in diabetic patients undergoing coronary artery bypass grafting: study protocol for a prospective, single-blind, randomized controlled trial
Preoperative carbohydrates (CHO) supplement has been widely investigated in nondiabetic patients undergoing a variety of surgeries. It has been proved that preoperative CHO could alleviate postoperative insuli...
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Article
Open AccessRNA N6-methyladenosine modification mediates downregulation of NR4A1 to facilitate malignancy of cervical cancer
N6-methyladenosine is the most abundant eukaryotic mRNA modification and alters a wide range of cellular processes in cancer. Therefore, defining the molecular details are critical for understanding the regulato....
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Article
Research on allocation efficiency of ecological tourism resources in Hunan Province
The exploration of approaches of efficiency improvement for the ecotourism resource allocation is conducive to the sustainable use of ecotourism resources and the high-quality development of the tourism indust...
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Article
Effects of multiple exposures to general anesthesia on the sleep quality of children after plastic surgery in Bei**g, China: a cohort study
To assess the effects of the number and duration of general anesthesia exposure on the sleep quality of 6–15-year-old school children who underwent plastic surgery. The study was conducted on 688 children who ...
