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Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology
This protocol describes assays for assessing heart rate fluctuations in mice or tissue isolated from mice, including by using in vivo telemetry and in vitro electrophysiology of intact sinoatrial network preparat...
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Article
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
DNA and histone modifications have notable effects on gene expression1. Being the most prevalent internal modification in mRNA, the N6-methyladenosine (m6A) mRNA modification is as an important post-transcription...
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Article
Open AccessJAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility
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Article
Open AccessInfectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID
The prerequisite to prevent childhood B-cell acute lymphoblastic leukemia (B-ALL) is to decipher its etiology. The current model suggests that infection triggers B-ALL development through induction of activati...
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Article
Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation
Recent reports have revealed that oligodendrocyte precursor cells (OPCs) are heterogeneous. It remains unclear whether such heterogeneity reflects different subtypes of cells with distinct functions or instead...
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Article
Open AccessRegional BCG vaccination policy in former East- and West Germany may impact on both severity of SARS-CoV-2 and incidence of childhood leukemia
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Open AccessPotential role of STAG1 mutations in genetic predisposition to childhood hematological malignancies
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Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants
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Open AccessThe Eμ-Ret mouse is a novel model of hyperdiploid B-cell acute lymphoblastic leukemia
The presence of supernumerary chromosomes is the only abnormality shared by all patients diagnosed with high-hyperdiploid B cell acute lymphoblastic leukemia (HD-ALL). Despite being the most frequently diagnos...