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7 Result(s)

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  1. Article

    Open Access

    Synaptic ribbons foster active zone stability and illumination-dependent active zone enrichment of RIM2 and Cav1.4 in photoreceptor synapses

    Rod photoreceptor synapses use large, ribbon-type active zones for continuous synaptic transmission during light and dark. Since ribbons are physically connected to the active zones, we asked whether illuminat...

    Ekta Dembla, Mayur Dembla, Stephan Maxeiner, Frank Schmitz in Scientific Reports (2020)

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  2. Article

    Open Access

    Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

    Ribbon synapses transmit information in sensory systems, but their development is not well understood. To test the hypothesis that ribbon assembly stabilizes nascent synapses, we performed simultaneous time-la...

    Haruhisa Okawa, Wan-Qing Yu, Ulf Matti, Karin Schwarz… in Nature Communications (2019)

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  3. No Access

    Article

    Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion

    Cytotoxic T lymphocytes kill virus-infected and tumorigenic target cells through the release of perforin and granzymes via fusion of lytic granules at the contact site, the immunological synapse. It has been p...

    Ulf Matti, Varsha Pattu, Mahantappa Halimani, Claudia Schirra… in Nature Communications (2013)

  4. No Access

    Article

    A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

    FOXO3 is a negative regulator of IRF7, a master regulator of the antiviral response.

    Vladimir Litvak, Alexander V. Ratushny, Aaron E. Lampano, Frank Schmitz… in Nature (2012)

  5. No Access

    Article

    RIM1α is required for presynaptic long-term potentiation

    Two main forms of long-term potentiation (LTP)—a prominent model for the cellular mechanism of learning and memory—have been distinguished in the mammalian brain1. One requires activation of postsynaptic NMDA (N-...

    Pablo E. Castillo, Susanne Schoch, Frank Schmitz, Thomas C. Südhof… in Nature (2002)

  6. No Access

    Article

    RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone

    Neurotransmitters are released by synaptic vesicle fusion at the active zone1,2. The active zone of a synapse mediates Ca2+-triggered neurotransmitter release, and integrates presynaptic signals in regulating thi...

    Susanne Schoch, Pablo E. Castillo, Tobias Jo, Konark Mukherjee, Martin Geppert… in Nature (2002)

  7. No Access

    Article

    Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

    Rab3 is a neuronal GTP-binding protein that regulates fusion of synaptic vesicles and is essential for long-term potentiation of hippocampal mossy fibre synapses1,2,3,4,5. More than thirty Rab GTP-binding protein...

    Yun Wang, Masaya Okamoto, Frank Schmitz, Kay Hofmann, Thomas C. Südhof in Nature (1997)