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  1. Article

    Open Access

    Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling

    Growth factor withdrawal induces rapid apoptosis via mitochondrial outer membrane permeabilization. We had previously observed that cell death of IL-3-dependent Ba/F3 cells, induced by removal of the growth fa...

    Florian Schubert, Juliane Rapp, Prisca Brauns-Schubert… in Cell Death & Disease (2018)

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  2. Article

    SPATA2: more than a missing link

    The assembly of the TNFR1 signalling complex (TNF-RSC) depends on K63- and M1-linked ubiquitylation, promoting the recruitment of complex constituents and the stability of the complex. Ubiquitylation is a dyna...

    Lisa Schlicher, Prisca Brauns-Schubert, Florian Schubert… in Cell Death & Differentiation (2017)

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  3. No Access

    Article

    Neurotransmitter changes during interference task in anterior cingulate cortex: evidence from fMRI-guided functional MRS at 3 T

    Neural activity as indirectly observed in blood oxygenation level-dependent (BOLD) response is thought to reflect changes in neurotransmitter flux. In this study, we used fMRI-guided functional magnetic resona...

    Simone Kühn, Florian Schubert, Ralf Mekle, Elisabeth Wenger… in Brain Structure and Function (2016)

  4. No Access

    Article

    Reduction of cerebellar grey matter in Crus I and II in schizophrenia

    Structural deficiencies within the cerebellum have been associated with schizophrenia. Whereas several region-of-interest-based studies have shown deviations in cerebellar volume, meta-analyses on conventional...

    Simone Kühn, Alexander Romanowski, Florian Schubert… in Brain Structure and Function (2012)

  5. No Access

    Article

    Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-β therapy on absolute metabolite concentrations

    To assess the applicability of magnetic resonance spectroscopy (MRS) for long-term follow-up of neurological diseases a longitudinal 1H-MRS study at 3 T was carried out on ten patients having relapsing-remitti...

    Florian Schubert, Frank Seifert… in Magnetic Resonance Materials in Physics, B… (2002)

  6. No Access

    Article

    Fibre optic fluorometric enzyme sensors for hydrogen peroxide and lactate, based on horseradish peroxidase and lactate oxidase

    An optical biosensor for the determination of hydrogen peroxide based on immobilized horseradish peroxidase is described. The fluorescence of the dimeric product of the enzyme catalysed oxidation of homovanill...

    Florian Schubert, Fang Wang, Herbert Rinneberg in Microchimica Acta (1995)

  7. No Access

    Chapter

    Multienzyme Biosensors — Coupled Enzyme Reactions and Enzyme Activation

    Traditionally enzymes are used as recognition elements to measure substrate molecules by catalyzing the turnover of these species to detectable products. The signal generation at biosensors using immobilized b...

    Frieder Scheller, Ulla Wollenberger… in Uses of Immobilized Biological Compounds (1993)