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Article
Open AccessRequirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling
Growth factor withdrawal induces rapid apoptosis via mitochondrial outer membrane permeabilization. We had previously observed that cell death of IL-3-dependent Ba/F3 cells, induced by removal of the growth fa...
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Article
SPATA2: more than a missing link
The assembly of the TNFR1 signalling complex (TNF-RSC) depends on K63- and M1-linked ubiquitylation, promoting the recruitment of complex constituents and the stability of the complex. Ubiquitylation is a dyna...