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Article
Open AccessTreatment Persistence and Switching Patterns of Adalimumab Biosimilar ABP 501 in European Patients with Rheumatologic Diseases
ABP 501 was an adalimumab (ADA) biosimilar approved for treating immune-mediated inflammatory diseases (IMIDs) including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). I...
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Article
Open AccessCoastal El Niño triggers rapid marine silicate alteration on the seafloor
Marine silicate alteration plays a key role in the global carbon and cation cycles, although the timeframe of this process in response to extreme weather events is poorly understood. Here we investigate surfac...
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Article
Open AccessBiogeochemical feedbacks may amplify ongoing and future ocean deoxygenation: a case study from the Peruvian oxygen minimum zone
A new box model is employed to simulate the oxygen-dependent cycling of nutrients in the Peruvian oxygen minimum zone (OMZ). Model results and data for the present state of the OMZ indicate that dissolved iron...
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Article
Open AccessInteractions between temperature and energy supply drive microbial communities in hydrothermal sediment
Temperature and bioavailable energy control the distribution of life on Earth, and interact with each other due to the dependency of biological energy requirements on temperature. Here we analyze how temperatu...
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Article
Open AccessMACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer
Metastasis Associated in Colon Cancer 1 (MACC1) is a novel prognostic, predictive and causal biomarker for tumor progression and metastasis in many cancer types, including colorectal cancer. Besides its clinic...
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Article
Periodic changes in the Cretaceous ocean and climate caused by marine redox see-saw
Periodic changes in sediment composition are usually ascribed to insolation forcing controlled by Earth’s orbital parameters. During the Cretaceous Thermal Maximum at 97–91 Myr ago (Ma), a 37–50-kyr-long cycle...
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Article
Benthic nematode biodiversity of the Abzu, Tiamat and Michael Ivanov mud volcanoes located along the SWIM fracture zone (Gulf of Cadiz)
Studies that focus on meiofaunal assemblages of deep-sea mud volcanoes show an unpredictable abundance and diversity in a clear response to the different environmental conditions of the seeped sediment. The mu...
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Article
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ
The capacity of dendritic cells (DCs) to regulate tumour-specific adaptive immune responses depends on their proper differentiation and homing status. Whereas DC-associated tumour-promoting functions are linke...
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Article
The impact of ocean deoxygenation on iron release from continental margin sediments
Bioavailable iron is released from anoxic sediments, such as those that underlie the Peruvian upwelling zone. Analyses of iron levels in sediments from this region suggest that iron release occurs in a relativ...
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Chapter and Conference Paper
How to Investigate Interaction with Information Visualisation: An Overview of Methodologies
Advanced information visualisation systems offer many different forms of interaction. Nevertheless, we do not know how useful these interactions are. Researchers have suggested to develop a science of interact...
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Chapter and Conference Paper
Evaluating the Dot-Based Contingency Wheel: Results from a Usability and Utility Study
The Dot-Based Contingency Wheel is an interactive visual-analytics method designed to discover and analyze positive associations in an asymmetrically large n ×m contingency table. Such tables summarize the relati...
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Chapter
Rahmenbedingungen von Psychotherapie und Beratung
Eine verantwortungsvolle psychotherapeutische Tätigkeit bewegt sich in einem gewissen rechtlichen Rahmen. Diesen zu kennen ist unerlässlich. Deswegen werden im Folgenden die wichtigsten Gesetze, Ordnungen und ...
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Article
Active mud volcanoes on the upper slope of the western Nile deep-sea fan—first results from the P362/2 cruise of R/V Poseidon
In February 2008, cruise P362/2 was undertaken aboard R/V Poseidon to the Giza and North Alex mud volcanoes (MVs) on the upper slope of the western Nile deep-sea fan. Emitted fluids were strongly depleted in chlo...
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Article
LerM – Lehrsystem für Kontrapunkt-Kompositionen im Stile Palestrinas
Der Palestrina-Kontrapunkt nimmt in der Musiktheorie-Ausbildung eine wichtige Stellung ein.
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Article
Viability and sunlight sensitivity of oak pollen and its implications for pollen-mediated gene flow
Pollen-mediated gene flow and the male reproductive success of wind-pollinated trees depend on the initial viability of the pollen and the changes that occur in its viability during transport in the atmosphere...
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Article
Einfluß eines erhöhten CO2-Gehaltes in der Luft auf Wachstumsparameter verschiedener Rotbuchen-Provenienzen (Fagus sylvatica L.) bei unterschiedlichem Lichtgenuß
Die Reaktion von sieben Provenienzen aus dem Verbreitungsgebiet der Rotbuche (Fagus sylvatica L.) auf erhöhte atmosphärische CO2-Konzentrationen bei unterschiedlichem Lichtangebot wurde in einem Gewächshausversuc...
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Article
Growth and protection against oxidative stress in young clones and mature spruce trees (Picea abies L.) at high altitudes
Clones of Norway spruce (Picea abies L.) were grown for several years on an altitudinal gradient (1750 m, 1150 m and 800 m above sea level) to study the effects of environmental × genetic interactions on growth ...
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Chapter
DNA Maxipreparations: A Comparison of Protocols for Rapid Extraction of Good Quality DNA from Recalcitrant Species
The application of specific molecular techniques, such as RFLP (restriction fragment length polymorphisms) (see Chapter 6) or AFLP (amplified fragment length polymorphisms) (see Chapter 10), or the constructio...
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Chapter
Methods for Difficult Plant Species/Tissues
All molecular genetic screening techniques start with the extraction of DNA from the organism under study and this is difficult when species and tissues high in polysaccharides and/or secondary metabolites suc...
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Article
Contribution of temperate forests to the world's carbon budget
Temperate forests currently cover about 600 MHa, about half of their potential. Almost all these forests have been directly impacted by humans. The total living biomass in trees (including roots) was estimated...
