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Article
Open AccessTreatment Persistence and Switching Patterns of Adalimumab Biosimilar ABP 501 in European Patients with Rheumatologic Diseases
ABP 501 was an adalimumab (ADA) biosimilar approved for treating immune-mediated inflammatory diseases (IMIDs) including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). I...
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Article
Open AccessCoastal El Niño triggers rapid marine silicate alteration on the seafloor
Marine silicate alteration plays a key role in the global carbon and cation cycles, although the timeframe of this process in response to extreme weather events is poorly understood. Here we investigate surfac...
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Article
Open AccessBiogeochemical feedbacks may amplify ongoing and future ocean deoxygenation: a case study from the Peruvian oxygen minimum zone
A new box model is employed to simulate the oxygen-dependent cycling of nutrients in the Peruvian oxygen minimum zone (OMZ). Model results and data for the present state of the OMZ indicate that dissolved iron...
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Article
Open AccessInteractions between temperature and energy supply drive microbial communities in hydrothermal sediment
Temperature and bioavailable energy control the distribution of life on Earth, and interact with each other due to the dependency of biological energy requirements on temperature. Here we analyze how temperatu...
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Article
Open AccessMACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer
Metastasis Associated in Colon Cancer 1 (MACC1) is a novel prognostic, predictive and causal biomarker for tumor progression and metastasis in many cancer types, including colorectal cancer. Besides its clinic...
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Chapter and Conference Paper
How to Investigate Interaction with Information Visualisation: An Overview of Methodologies
Advanced information visualisation systems offer many different forms of interaction. Nevertheless, we do not know how useful these interactions are. Researchers have suggested to develop a science of interact...
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Chapter and Conference Paper
Evaluating the Dot-Based Contingency Wheel: Results from a Usability and Utility Study
The Dot-Based Contingency Wheel is an interactive visual-analytics method designed to discover and analyze positive associations in an asymmetrically large n ×m contingency table. Such tables summarize the relati...
