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Article
Heterochromatin Protein 1 Deleted Chromo Domain Decreases Gene Silencing of Transgene in Mouse
The heterochromatin protein 1 (HP1) regulates epigenetic gene silencing by promoting and maintaining chromatin condensation. To decrease gene silencing, the chromo domain (CD) in the M31 (the main HP1 in mouse...
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Article
Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein
Accumulation of α-synuclein (α-Syn) is a common pathology for both familiar and sporadic Parkinson’s disease (PD), enhancing its clearance might be a promising strategy for treating PD. To assess the potential...
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Article
Open AccessUbiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing
Quantum dots (QDs) have attracted increasing interest in bioimaging and sensing. Here, we report a biosensor of complex I using ubiquinone-terminated disulphides with different alkyl spacers (QnNS, n = 2, 5 and...
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Article
Correction: Corrigendum: Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing
Quantum dots (QDs) have attracted increasing interest in bioimaging and sensing. Here, we report a biosensor of complex I using ubiquinone-terminated disulphides with different alkyl spacers (QnNS, n = 2, 5 and...
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Article
Trehalose Alleviates PC12 Neuronal Death Mediated by Lipopolysaccharide-Stimulated BV-2 Cells via Inhibiting Nuclear Transcription Factor NF-κB and AP-1 Activation
Inflammation is implicated in the pathogenesis of Parkinson’s disease (PD). Trehalose is a disaccharide which exhibits a variety of effects like anti-aggregation, autophagy enhancement in PD. It has also been ...
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Article
Open AccessDesign, synthesis and biological evaluation of hybrids of β-carboline and salicylic acid as potential anticancer and apoptosis inducing agents
A novel series of hybrids (7a-l, 8a-l) from β-carboline and salicylic acid (SA) were designed and synthesized, and their in vitro biological activities were evaluated. Most of the hybrids displayed potent antipro...
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Article
Open AccessA homozygous missense variant in HSD17B4 identified in a consanguineous Chinese Han family with type II Perrault syndrome
Perrault syndrome is a rare multisystem disorder that manifests with sensorineural hearing loss in both sexes, primary ovarian insufficiency in females and neurological features. The syndrome is heterogeneous ...
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Article
Open AccessEvaluation of PDQ-8 and its relationship with PDQ-39 in China: a three-year longitudinal study
Parkinson’s disease is characterized by motor and non-motor symptoms with wide ranging impacts on the health-related quality of life. The 39-item Parkinson’s disease Questionnaire (PDQ-39) is the most widely u...
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Article
Update on Molecular Imaging in Parkinson’s Disease
Advances in radionuclide tracers have allowed for more accurate imaging that reflects the actions of numerous neurotransmitters, energy metabolism utilization, inflammation, and pathological protein accumulati...
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Article
Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease characterized by the formation of protein inclusion and progressive loss of motor neurons, finally leading to muscle weak...
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Article
Open AccessCognitive characteristics in Chinese non-demented PD patients based on gender difference
Cognitive impairment is one of the non-motor symptoms in Parkinson’s disease (PD). In the present study, we aim to examine the cognitive function of non-demented Parkinson’s disease patients and compare the re...
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Article
Considerations before initiating therapy in Parkinsonism: basing on the quality of life
Improvement of quality-of-life (QoL) has been termed as a primary objective in initiating therapy in both Parkinson’s disease (PD) and multiple system atrophy Parkinsonian subtype (MSA-P). We aimed to compare ...
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Article
Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction
The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson’s disease (EOPD) patients and carriers of Parkin mutations on non-motor symptoms (NMSs). EOPD patient...
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Article
Open AccessShort-echo-time magnitude image derived from quantitative susceptibility map** could resemble neuromelanin-sensitive MRI image in substantia nigra
In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility map** (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantita...
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Article
Neuroprotection of Exendin-4 by Enhanced Autophagy in a Parkinsonian Rat Model of α-Synucleinopathy
Glucagon-like peptide-1 (GLP-1) receptor stimulation ameliorates parkinsonian motor and non-motor deficits in both experimental animals and patients; however, the disease-modifying mechanisms of GLP-1 receptor...
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Article
Diagnosis and surgical treatment of non-lesional temporal lobe epilepsy with unilateral amygdala enlargement
Exploring the role of amygdala enlargement (AE) in temporal lobe epilepsy (TLE) without ipsilateral mesial temporal sclerosis (MTS) using comprehensive presurgical workup tools including traditional tools, aut...
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Article
Predictors of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis of prospective cohort studies
Cognitive impairment is a debilitating manifestation in Parkinson’s disease (PD). We sought to investigate predictors of PD-CI (PD with cognitive impairment).
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Article
Morphological description of desiccation cracks in soils: insights from the perspective of anisotropy
The characterization of a soil crack network requires a comprehensive understanding of statistics and has been of longstanding interest but not well resolved. By performing a series of desiccation cracking tes...
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Article
Open AccessComparison of comfort and complications of Implantable Venous Access Port (IVAP) with ultrasound guided Internal Jugular Vein (IJV) and Axillary Vein/Subclavian Vein (AxV/SCV) puncture in breast cancer patients: a randomized controlled study
Axillary vein/subclavian vein (AxV/SCV) and Internal jugular vein (IJV) are commonly used for implantable venous access port (IVAP) implantation in breast cancer patients for chemotherapy. Previous research fo...
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Article
Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson’s disease
Our aim is to investigate the associations of sleep disorders with cerebrospinal fluid (CSF) α-synuclein (α-syn) in healthy controls (HCs), and patients with prodromal and early Parkinson’s disease (PD).
