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  1. No Access

    Article

    Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein

    Accumulation of α-synuclein (α-Syn) is a common pathology for both familiar and sporadic Parkinson’s disease (PD), enhancing its clearance might be a promising strategy for treating PD. To assess the potential...

    Dan-Mei Lan, Feng-Tao Liu, Jian Zhao, Yan Chen, Jian-Jun Wu… in Neurochemical Research (2012)

  2. No Access

    Article

    Trehalose Alleviates PC12 Neuronal Death Mediated by Lipopolysaccharide-Stimulated BV-2 Cells via Inhibiting Nuclear Transcription Factor NF-κB and AP-1 Activation

    Inflammation is implicated in the pathogenesis of Parkinson’s disease (PD). Trehalose is a disaccharide which exhibits a variety of effects like anti-aggregation, autophagy enhancement in PD. It has also been ...

    Qing He, Ying Wang, Wei Lin, Qiong Zhang, Jue Zhao, Feng-Tao Liu… in Neurotoxicity Research (2014)

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    Article

    Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation

    Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease characterized by the formation of protein inclusion and progressive loss of motor neurons, finally leading to muscle weak...

    Ying Wang, Feng-Tao Liu, Yi-Xuan Wang, Rong-Yuan Guan, Chen Chen… in Neurotoxicity Research (2018)

  4. No Access

    Article

    Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction

    The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson’s disease (EOPD) patients and carriers of Parkin mutations on non-motor symptoms (NMSs). EOPD patient...

    Jie Song, Bo Shen, Yu-Jie Yang, Feng-tao Liu, Jue Zhao… in Journal of Molecular Neuroscience (2020)