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Article
Clinical features, disease progression, and nuclear imaging in ATXN2-related parkinsonism in a longitudinal cohort
Spinocerebellar ataxia 2 (SCA2) with a low range of CAG repeat expansion of ATXN2 gene can present with predominant or isolated parkinsonism that closely resembles Parkinson’s disease (PD). This study is aimed at...
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Article
Open Access18F-Florzolotau PET imaging captures the distribution patterns and regional vulnerability of tau pathology in progressive supranuclear palsy
Human post mortem studies have described the topographical patterns of tau pathology in progressive supranuclear palsy (PSP). Recent advances in tau PET tracers are expected to herald the next era of PSP inves...
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Article
Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson’s disease
Our aim is to investigate the associations of sleep disorders with cerebrospinal fluid (CSF) α-synuclein (α-syn) in healthy controls (HCs), and patients with prodromal and early Parkinson’s disease (PD).
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Article
Predictors of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis of prospective cohort studies
Cognitive impairment is a debilitating manifestation in Parkinson’s disease (PD). We sought to investigate predictors of PD-CI (PD with cognitive impairment).
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Article
Diagnosis and surgical treatment of non-lesional temporal lobe epilepsy with unilateral amygdala enlargement
Exploring the role of amygdala enlargement (AE) in temporal lobe epilepsy (TLE) without ipsilateral mesial temporal sclerosis (MTS) using comprehensive presurgical workup tools including traditional tools, aut...
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Article
Open AccessShort-echo-time magnitude image derived from quantitative susceptibility map** could resemble neuromelanin-sensitive MRI image in substantia nigra
In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility map** (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantita...
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Article
Considerations before initiating therapy in Parkinsonism: basing on the quality of life
Improvement of quality-of-life (QoL) has been termed as a primary objective in initiating therapy in both Parkinson’s disease (PD) and multiple system atrophy Parkinsonian subtype (MSA-P). We aimed to compare ...
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Article
Open AccessEvaluation of PDQ-8 and its relationship with PDQ-39 in China: a three-year longitudinal study
Parkinson’s disease is characterized by motor and non-motor symptoms with wide ranging impacts on the health-related quality of life. The 39-item Parkinson’s disease Questionnaire (PDQ-39) is the most widely u...