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  1. Article

    Open Access

    Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER–mitochondrial dynamics

    Hexadimethrine bromide (Polybrene) was once used clinically as a heparin neutralizer and has recently found use as a promoter in virus-mediated gene therapy trials and gene transfer in research. However, the p...

    Feixiang Bao, Hongyan Shi, Mi Gao, Liang Yang, Lingyan Zhou… in Cell Death & Disease (2018)

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  2. No Access

    Article

    Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA

    Heteroplasmic cells, harboring both mutant and normal mitochondrial DNAs (mtDNAs), must accumulate mutations to a threshold level before respiratory activity is affected. This phenomenon has led to the hypothe...

    Liang Yang, Qi Long, **glei Liu, Haite Tang… in Cellular and Molecular Life Sciences (2015)