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Article
Highly stable two-dimensional AgCrSe2 membranes reinforced by polydopamine for contaminated water purification
Two-dimensional (2D) nanosheet membranes exhibit significant potential for molecular and ionic separation. Nonetheless, these membranes encounter swelling and oxidation issues when applied for the wastewater t...
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Article
Open AccessSpectrum and characteristics of germline PALB2 pathogenic variants in 1556 early-onset breast cancer patients in China
Limited data are available regarding the partner and localizer of BRCA2 (PALB2) in Chinese patients with early breast cancer. This study aimed to assess the spectrum and characteristics of germline PALB2 pathogen...
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Article
Open AccessYY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway
Triple-negative breast cancer (TNBC) is more aggressive and has a higher metastasis rate compared with other subtypes of breast cancer. Due to the lack of drug-targetable receptors, chemotherapy is now the onl...
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Article
Open AccessSingle-cell transcriptomic landscape and the microenvironment of normal adjacent tissues in hypopharyngeal carcinoma
The cellular origin of hypopharyngeal diseases is crucial for further diagnosis and treatment, and the microenvironment in tissues may also be associated with specific cell types at the same time. Normal adjac...
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Article
Open AccessExploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer
The histological grade is an important factor in the prognosis of invasive breast cancer and is vital to accurately identify the histological grade and reclassify of Grade2 status in breast cancer patients.
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Article
Prognostic significance of collagen signatures at breast tumor boundary obtained by combining multiphoton imaging and imaging analysis
Collagen features in breast tumor microenvironment is closely associated with the prognosis of patients. We aim to explore the prognostic significance of collagen features at breast tumor border by combining m...
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Article
Comparative efficacy and safety of extended adjuvant endocrine therapy for hormone receptor-positive early breast cancer: a Bayesian network meta-analysis
Optimal extended adjuvant endocrine therapy (ET) duration and strategy for hormone receptor-positive (HR +) early breast cancer remain unclear. In this network meta-analysis (NMA), the efficacy and safety of a...
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Article
Open AccessThe identification, characterization, and management of Rotylenchulus reniformis on Cucumis melo in China
The reniform nematode, Rotylenchulus reniformis, is a sedentary root parasite that poses a significant threat to agricultural production in tropical and subtropical regions worldwide. In 2021–2022, a population o...
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Article
Open AccessCorrelation between AI-based CT organ features and normal lung dose in adjuvant radiotherapy following breast-conserving surgery: a multicenter prospective study
Radiation pneumonitis (RP) is one of the common side effects after adjuvant radiotherapy in breast cancer. Irradiation dose to normal lung was related to RP. We aimed to propose an organ features based on deep...
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Article
Identify spatio-temporal properties of network traffic by model checking
Cellular networks have been widely deployed and are under ever-growing pressure from increasing energy consumption. Identifying the spatio-temporal properties of network traffic is crucial to effectively manag...
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Article
Open AccessPrognostic value of tumor necrosis based on the evaluation of frequency in invasive breast cancer
Tumor necrosis (TN) was associated with poor prognosis. However, the traditional classification of TN ignored spatial intratumor heterogeneity, which may be associated with important prognosis. The purpose of ...
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Article
Open AccessImpact of body mass index in therapeutic response for HER2 positive breast cancer treated with neoadjuvant targeted therapy: a multi-center study and meta-analysis
While overweight/obesity has become a major public health issue worldwide, any association between body mass index (BMI) and therapeutic response in neoadjuvant targeted therapy treated HER2 positive breast ca...
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Article
Open AccessHigh leukocyte mitochondrial DNA copy number contributes to poor prognosis in breast cancer patients
Compelling evidence has indicated a significant association between leukocyte mitochondrial DNA copy number (mtDNAcn) and prognosis of several malignancies in a cancer-specific manner. However, whether leukocy...
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Article
Excitation orthogonalized upconversion nanoprobe for instant visual detection of trinitrotoluene
Excitation-emission orthogonalized luminescent upconversion nanoparticles (OUCNPs), which can respond to changes in external stimuli accordingly, show great promise in many intelligent applications. However, t...
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Article
Open AccessClinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients
Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit f...
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Article
Improved false-negative rates using a novel patient selection flowchart in initially biopsy-proven node-positive breast cancer undergoing blue-dye alone guided sentinel lymph node biopsy after neoadjuvant chemotherapy
Current trials support the application of sentinel lymph node biopsy (SLNB) in node-positive breast cancer treated with neoadjuvant chemotherapy (NAC) with a lower false-negative rate (FNR) if dual-tracer (rad...
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Article
Open AccessIntratumor graph neural network recovers hidden prognostic value of multi-biomarker spatial heterogeneity
Biomarkers are indispensable for precision medicine. However, focused single-biomarker development using human tissue has been complicated by sample spatial heterogeneity. To address this challenge, we tested ...
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Article
Open AccessSelf-Assembly 3D Porous Crumpled MXene Spheres as Efficient Gas and Pressure Sensing Material for Transient All-MXene Sensors
3D porous crumpled MXene spheres were synthesized by ultrasonic spray pyrolysis technology.
All-M...
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Article
Open AccessCTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1
Cytidine nucleotide triphosphate synthase 1 (CTPS1) is a CTP synthase which play critical roles in DNA synthesis. However, its biological regulation and mechanism in triple-negative breast cancer (TNBC) has no...
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Article
Open AccessComputer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer
Collagen fibers play an important role in tumor initiation, progression, and invasion. Our previous research has already shown that large-scale tumor-associated collagen signatures (TACS) are powerful prognost...
