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  1. No Access

    Article

    Recombinant Lactococcus lactis expressing bioactive exendin-4 to promote insulin secretion and beta-cell proliferation in vitro

    In recent years, therapeutic peptides have garnered great interest in the pharmaceutical industry for the treatment of diabetes. Lactic acid bacteria (LAB) are an appealing vehicle for safe and convenient oral...

    Zhu Zeng, Rui Yu, Fanglei Zuo, Bo Zhang… in Applied Microbiology and Biotechnology (2017)

  2. No Access

    Article

    Characterization and in vitro properties of potential probiotic Bifidobacterium strains isolated from breast-fed infant feces

    Probiotics are live microorganisms that when administered in adequate amounts, confer health benefits on the host. In this study, 13 strains of Bifidobacterium were isolated from three samples of breast-fed infan...

    Fanglei Zuo, Rui Yu, **ujuan Feng, Lili Chen, Zhu Zeng… in Annals of Microbiology (2016)

  3. Article

    Open Access

    Recombinant Lactococcus lactis NZ9000 secretes a bioactive kisspeptin that inhibits proliferation and migration of human colon carcinoma HT-29 cells

    Proteinaceous bioactive substances and pharmaceuticals are most conveniently administered orally. However, the facing problems are the side effects of proteolytic degradation and denaturation in the gastrointe...

    Bo Zhang, Angdi Li, Fanglei Zuo, Rui Yu, Zhu Zeng, Huiqin Ma… in Microbial Cell Factories (2016)

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  4. No Access

    Article

    Overexpression of Small Heat Shock Protein Enhances Heat- and Salt-Stress Tolerance of Bifidobacterium longum NCC2705

    Bifidobacteria are probiotics that are incorporated live into various dairy products. They confer health-promotive effects via gastrointestinal tract colonization. However, to provide their health-beneficial p...

    Gul Bahar Khaskheli, FangLei Zuo, Rui Yu, ShangWu Chen in Current Microbiology (2015)

  5. No Access

    Article

    Combination of heterogeneous catalase and superoxide dismutase protects Bifidobacterium longum strain NCC2705 from oxidative stress

    Bifidobacteria are generally sensitive to oxidative stress caused by reactive oxygen species (ROS). To improve oxidative-stress tolerance, the superoxide dismutase (SOD) gene from Streptococcus thermophilus (StSo...

    Fanglei Zuo, Rui Yu, **ujuan Feng… in Applied Microbiology and Biotechnology (2014)

  6. No Access

    Article

    Characterization of Plasmid pML21 of Enterococcus faecalis ML21 from Koumiss

    Fanglei Zuo, **ujuan Feng, **aofei Sun, Chao Du, Shangwu Chen in Current Microbiology (2013)