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Article
Effect of age on the binding of lectin125I-PHA-B to pancreatic islets of ratin vitro and stimulation of some cellular events
Agaricus bisporus lectin (PHA-B) stimulates insulin releasein vitro. The stimulation is associated with increased conversion of proinsulin to insulin in the isolated islets of Langerhans ...
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Article
Effect of some novel synthetic analogues of CCK-4 on insulin and glucagon secretion
The biologic activities of three synthetic analogues of CCK-4 (Trp-Met-Asp-Phe-NH2) in which (i) the C-terminal residue Phe was N-methylated (peptide I); (ii) the C-terminal Phe residue was N-methylated and Ser i...
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Article
Insulin like activity in (−) epicatechin
Water extract of the bark of plant ofPterocarpus marsupium Roxb is used as an antidiabetic drug in indigenous medicine in India. (−) Epicatechin, its active principle, has been found to be insulinogenic. The pres...
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Article
Selective stimulation of insulin secretion by CCK-4 analogues having N-terminal modifications
Synthetic analogues of CCK-4 in which Trp1 was replaced by D-Pro (peptide I), Thz (peptide II) and ΔPro (peptide III) have been studied for their insulin and glucagon releasing activities from the islets of Lange...
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Article
Insulin and glucagon releasing activity of coleonol (forskolin) and its effect on blood glucose level in normal and alloxan diabetic rats
Colenol, a diterpenoid isolated from the roots ofColeus forskohlii stimulates the release of insulin and glucagon from the islets bothin vitro andin vivo. Coleonol-stimulated release of glucagon from isletsin vit...