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  1. No Access

    Article

    Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

    Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus formation. We demonstrate that induction of ...

    Fabio Pessina, Fabio Giavazzi, Yandong Yin, Ubaldo Gioia… in Nature Cell Biology (2019)

  2. No Access

    Article

    Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

    The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR activation. Here we show that active DDR...

    Flavia Michelini, Sethuramasundaram Pitchiaya, Valerio Vitelli… in Nature Cell Biology (2017)