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  1. No Access

    Article

    Clinical outcomes and complications of S53P4 bioactive glass in chronic osteomyelitis and septic non-unions: a retrospective single-center study

    Dead space management following debridement surgery in chronic osteomyelitis or septic non-unions is one of the most crucial and discussed steps for the success of the surgical treatment of these conditions. I...

    Simone Daniel Gatti, Diego Gaddi… in European Journal of Clinical Microbiology … (2024)

  2. Article

    Open Access

    Telomere damage induces internal loops that generate telomeric circles

    Extrachromosomal telomeric circles are commonly invoked as important players in telomere maintenance, but their origin has remained elusive. Using electron microscopy analysis on purified telomeres we show tha...

    Giulia Mazzucco, Armela Huda, Martina Galli, Daniele Piccini… in Nature Communications (2020)

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  3. No Access

    Article

    Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

    Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus formation. We demonstrate that induction of ...

    Fabio Pessina, Fabio Giavazzi, Yandong Yin, Ubaldo Gioia… in Nature Cell Biology (2019)

  4. No Access

    Article

    Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

    The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR activation. Here we show that active DDR...

    Flavia Michelini, Sethuramasundaram Pitchiaya, Valerio Vitelli… in Nature Cell Biology (2017)