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Article
Open AccessPredicting receptor-ligand pairs through kernel learning
Regulation of cellular events is, often, initiated via extracellular signaling. Extracellular signaling occurs when a circulating ligand interacts with one or more membrane-bound receptors. Identification of r...
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Article
Open AccessCandidate gene prioritization by network analysis of differential expression using machine learning approaches
Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available. Performing genetic studies frequently re...
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Article
Open AccessA kernel-based integration of genome-wide data for clinical decision support
Although microarray technology allows the investigation of the transcriptomic make-up of a tumor in one experiment, the transcriptome does not completely reflect the underlying biology due to alternative splic...