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  1. No Access

    Article

    Improvement of spontaneous speech in early stage Alzheimer’s disease with rivastigmine

    Placebo-controlled trials have shown that rivastigmine can delay cognitive deterioration in patients with mild to moderate Alzheimer’s disease (AD). Benefits on cognitive functioning, as measured with the ADAS...

    E. G. Visch-Brink, W. Van Rhee-Temme… in JNHA - The Journal of Nutrition, Health an… (2009)

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    Article

    Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala→Gly mutation

    Mutations at codons 717 and 670/671 in the amyloid precursor protein (APP) are rare genetic causes of familial Alzheimer’s disease (AD). A mutation at codon 693 of APP has also been described as the genetic d...

    P. Cras, F. van Harskamp, L. Hendriks, C. Ceuterick… in Acta Neuropathologica (1998)

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    Article

    Abnormal amino acid metabolism in patients with early stage Alzheimer dementia

    Plasma levels of several amino acids were studied in 14 patients with early stage probable Alzheimer's disease (AD) and 17 age-matched controls. In the AD patients a possible relationship between amino acid l...

    D. Fekkes, T. J. M. van der Cammen, C. P. M. van Loon… in Journal of Neural Transmission (1998)

  4. Article

    Association of diabetes mellitus and dementia: The Rotterdam Study

    Dementia and non-insulin-dependent diabetes mellitus (NIDDM) are highly prevalent disorders in the elderly. Diabetes has repeatedly been reported to affect cognition, but its relation with dementia is uncerta...

    A. Ott, R. P. Stolk, A. Hofman, F. van Harskamp, D. E. Grobbee… in Diabetologia (1996)

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    Article

    Vascular risk factors, atherosclerosis, cerebral white matter lesions and cerebral perfusion in a population-based study

    We studied risk factors for cerebral vascular disease (blood pressure and hypertension, factor VIIc, factor VIIIc, fibrinogen), indicators of atherosclerosis (intima-media thickness and plaques in the carotid ...

    J. J. Claus, M. M. B. Breteler, D. Hasan… in European Journal of Nuclear Medicine (1996)

  6. No Access

    Article

    Assessment of cerebral perfusion with single-photon emission tomography in normal subjects and in patients with Alzheimer's disease: effects of region of interest selection

    The shape, size and location of regions of interest (ROls) show considerable variability between single-photon emission tomography (SPET) studies in aging and Alzheimer's disease, but the possible influence on...

    J. J. Claus, F. van Harskamp, M. M. B. Breteler… in European Journal of Nuclear Medicine (1994)