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Open AccessComparing coronary artery cross-sectional area among asymptomatic South Asian, White, and Black participants: the MASALA and CARDIA studies
South Asian individuals have high risk of atherosclerotic cardiovascular disease (ASCVD). Some investigators suggest smaller coronary artery size may be partially responsible.
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FiLaC® and Crohn’s disease perianal fistulas: a pilot study of 20 consecutive patients
The aim of our study was to evaluate the efficacy of FiLaC® (Fistula Laser Closure) in the treatment of perianal fistulas in patients with Crohn’s disease.
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Endovascular Extra-Anatomic Femoro-Popliteal Bypass for Limb Salvage in Chronic Critical Limb Ischemia
To report the initial clinical experience with fully endovascular extra-anatomic femoro-popliteal bypass (FPB) for limb salvage in patients with critical limb ischemia (CLI) and no traditional endovascular or ...
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Targeted spine strengthening exercise and posture training program to reduce hyperkyphosis in older adults: results from the study of hyperkyphosis, exercise, and function (SHEAF) randomized controlled trial
A 6-month randomized controlled trial of spine-strengthening exercise and posture training reduced both radiographic and clinical measures of kyphosis. Participants receiving the intervention improved self-ima...
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Less favorable body composition and adipokines in South Asians compared with other US ethnic groups: results from the MASALA and MESA studies
Small studies have shown that South Asians (SAs) have more total body, subcutaneous, visceral and hepatic fat and abnormal adipokine levels compared with Whites. However, comprehensive studies of body composit...
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Stress regulation as a link between executive function and pre-frailty in older adults
Both pre-frailty and frailty are linked with impaired executive function (EF) but the mechanism underlying this relationship is not known. Williams and colleagues’ model posits EF affects health outcomes via s...
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TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation
The biological outcome of TMPRSS2:ERG chromosomal translocations in prostate cancer (PC) remains poorly understood. To address this, we compared the transcriptional effects of TMPRSS2:ERG expression in a transgen...
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Open AccessA certified plasmid reference material for the standardisation of BCR–ABL1 mRNA quantification by real-time quantitative PCR
Serial quantification of BCR–ABL1 mRNA is an important therapeutic indicator in chronic myeloid leukaemia, but there is a substantial variation in results reported by different laboratories. To improve comparabil...
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Nutrient biomarkers and vascular risk factors in subtypes of mild cognitive impairment: A cross-sectional study
To investigate the interrelationships among blood nutrient biomarkers, the Framingham Stroke Risk Profile (FSRP), and cognitive impairment features in mild cognitive impairment (MCI) subjects and to verify whe...
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Panax notoginseng saponins improve the erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum
Diabetes mellitus (DM)-associated ED is predominantly due to neurovascular dysfunction mediated by nitric oxide (NO) suppression. Panax notoginseng saponins (PNS) are widely used for treating cardiovascular di...
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Association among serum uric acid, cardiovascular risk, and arterial stiffness: A cross-sectional study in She ethnic minority group of Fujian Province in China
Objectives: To investigate the association between serum uric acid levels, cardiovascular risk, and arterial stiffness in She ethnic minority in South China’s Fujian Province. Methods: 51...
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Felsenbeinchirurgie
Das geflügelte Wort von „no surgeries, no surgical complications“ trifft auch für die Ohrchirurgie zu. Im englischen Sprachraum werden 3 ungünstige Folgen einer Operation (Op.) begrifflich unterschieden: „sequ...
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Open AccessIdentifICATION OF E3 ubiquitin ligase STUB1 as a negative regulator of FOXP3
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Detection and molecular monitoring of FIP1L1-PDGFRA-positive disease by analysis of patient-specific genomic DNA fusion junctions
To evaluate current detection methods for FIP1L1-PDGFRA in hypereosinophilic syndrome (HES), we developed a means to rapidly amplify genomic break points. We screened 202 cases and detected genomic junctions in a...
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Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77 translocation is induced by certain apoptotic stim...
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Comparing whole body 18F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphonate bone scan to detect bone metastases in patients with breast cancer
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Expression of inflammatory cytokines and beta-defensin 1 mRNAs in porcine epithelial rests of Malassez in vitro
In the present study, we investigated the mRNA expression of inflammatory cytokines, including interleukin (IL)-1α, IL-6, IL-8, and granulocyte macrophage colony-stimulating factor (GM-CSF), and β defensin 1 ...
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Selected abstracts
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Adoptive immunotherapy for relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: equal efficacy of lymphocytes from sibling and matched unrelated donors
Lymphocyte transfusion from the marrow donor (DLT) is well established as an effective therapy for relapse of CML post allogeneic BMT. Reports thus far have been mostly limited to patients who received DLT fro...
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Dietary calcium intake, physical activity and the risk of vertebral fracture in Chinese
To study the relationship between dietary calcium intake, load-bearing activity, reproductive factors, anthropometric factors and vertebral fracture in Chinese, a case-control study was carried out on 481 wome...