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  1. No Access

    Article

    Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

    The DNA-damage response (DDR) pathways consist of interconnected components that respond to DNA damage to allow repair and promote cell survival. The DNA repair pathways and downstream cellular responses have ...

    F Al-Ejeh, R Kumar, A Wiegmans, S R Lakhani, M P Brown, K K Khanna in Oncogene (2010)

  2. No Access

    Article

    Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11

    Mutations of p53 in cancer can result in a gain of function associated with tumour progression and metastasis. We show that inducible expression of several p53 ‘hotspot’ mutants promote a range of centrosome a...

    J E Noll, J Jeffery, F Al-Ejeh, R Kumar, K K Khanna, D F Callen, P M Neilsen in Oncogene (2012)

  3. Article

    Open Access

    Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

    Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking expression of estrogen and progesterone receptors (ER/PR) and HER2, thus limiting therapy options. We hypothesized that meta-...

    F Al-Ejeh, P T Simpson, J M Sanus, K Klein, M Kalimutho, W Shi, M Miranda… in Oncogenesis (2014)

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  4. Article

    Erratum: Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

    Correction to: Oncogenesis (2014) 3, e100; doi:10.1038/oncsis.2014.14; published online 21 April 2014 Since the publication of the above manuscript the authors have identified an error in the author list; the ...

    F Al-Ejeh, P T Simpson, J M Saunus, K Klein, M Kalimutho, W Shi, M Miranda… in Oncogenesis (2014)

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  5. Article

    Open Access

    EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia

    The human EphA3 gene was discovered in a pre-B acute lymphoblastic leukemia (pre-B-ALL) using the EphA3-specific monoclonal antibody (mAb), IIIA4, which binds and activates both human and mouse EphA3. We use t...

    S Charmsaz, F Al-Ejeh, T M Yeadon, K J Miller, F M Smith, B W Stringer… in Leukemia (2017)

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