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    Reductive carboxylation supports growth in tumour cells with defective mitochondria

    Tumour cells with defective mitochondria are found to use glutamine-dependent reductive carboxylation, rather than oxidative metabolism, as the major pathway of citrate and lipid formation.

    Andrew R. Mullen, William W. Wheaton, Eunsook S. **, Pei-Hsuan Chen… in Nature (2012)