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Article
Open AccessSpatial transcriptomic brain imaging reveals the effects of immunomodulation therapy on specific regional brain cells in a mouse dementia model
Increasing evidence of brain-immune crosstalk raises expectations for the efficacy of novel immunotherapies in Alzheimer’s disease (AD), but the lack of methods to examine brain tissues makes it difficult to e...
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Article
Open AccessCurrent updates relating to treatment for interstitial cystitis/bladder pain syndrome: systematic review and network meta-analysis
Despite the publication of several meta-analyses regarding the efficacy of certain therapies in hel** individuals with interstitial cystitis (IC) / bladder pain syndrome (BPS), these have not provided a comp...
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Article
Open AccessThe secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation
Akkermansia muciniphila has received great attention because of its beneficial roles in gut health by regulating gut immunity, promoting intestinal epithelial development, and improving barrier integrity. However...
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Article
Open AccessComparison of the diagnostic performance of the Swischuk line method and the anterior atlantodental interval method in atlantodental subluxation
Atlantodental subluxation (ADS) is a serious condition that can result in sudden death. Measuring the anterior atlantodental interval (AADI method) is the gold standard for diagnosis but the complex anatomy of...
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Article
Open AccessSpatiotemporal characterization of glial cell activation in an Alzheimer’s disease model by spatially resolved transcriptomics
The molecular changes that occur with the progression of Alzheimer’s disease (AD) are well known, but an understanding of the spatiotemporal heterogeneity of changes in the brain is lacking. Here, we investiga...
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Article
Utility of accelerated T2-weighted turbo spin-echo imaging with deep learning reconstruction in female pelvic MRI: a multi-reader study
To determine the clinical feasibility of T2-weighted turbo spin-echo (T2-TSE) imaging with deep learning reconstruction (DLR) in female pelvic MRI compared with conventional T2 TSE in terms of image quality an...
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Article
Rapidly progressive dementia with severe insomnia: an unusual case of progressive supranuclear palsy mimicking dementia with Lewy bodies
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Article
Open AccessDevelopment of a deep learning system to detect glaucoma using macular vertical optical coherence tomography scans of myopic eyes
Myopia is one of the risk factors for glaucoma, making accurate diagnosis of glaucoma in myopic eyes particularly important. However, diagnosis of glaucoma in myopic eyes is challenging due to the frequent ass...
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Article
Open AccessDiscrepancy between peripapillary retinal and choroidal microvasculature and the rate of localized retinal nerve fiber layer thinning in glaucoma
This observational case series study is conducted to compare the extent of microvasculature impairment in the peripapillary retina and choroid in eyes with primary open-angle glaucoma (POAG), and to investigat...
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Article
Open AccessSystemic factors associated with 10-year glaucoma progression in South Korean population: a single center study based on electronic medical records
Glaucoma is a multifactorial disease where various systemic features are involved in the progression of the disease. Based on initial systemic profiles in electronic medical records, this study aimed to develo...
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Article
Open AccessContrast sensitivity in glaucoma patients with visual field defects at different locations
Contrast sensitivity (CS) is closely associated with vision-related quality of life in glaucoma patients. This cross-sectional study was performed to determine the relationship between CS and visual field (VF)...
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Article
Open AccessProspective analysis of breast masses using the combined score for quantitative ultrasonography parameters
To investigate the diagnostic value of combined SWE, SMI, and B-mode US scores for distinguishing between benign and malignant masses. A total of 450 breast masses that underwent US-guided core needle biopsies...
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Article
Open AccessAuthor Correction: Prime editor-mediated correction of a pathogenic mutation in purebred dogs
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Open AccessPrime editor-mediated correction of a pathogenic mutation in purebred dogs
Canine hip dysplasia (HD) is a multifactorial disease caused by interactions between genetic and environmental factors. HD, which mainly occurs in medium- to large-sized dogs, is a disease that causes severe p...
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Article
Open AccessEstablishment of a piglet model for peritoneal metastasis of ovarian cancer
A piglet model for peritoneal metastasis (PM) of ovarian cancer was developed. It will contribute to establishing innovative chemotherapeutical and surgical strategies without any limitation on rodent models.
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Article
Open AccessAssociations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson’s disease
The risk factors of mild cognitive impairment (MCI) in patients with de novo Parkinson’s disease (PD) remain unclear. Therefore, the objective of this study was to compare motor and non-motor symptoms between ...
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Article
Open AccessDifference in topographic morphology of optic nerve head and neuroretinal rim between normal tension glaucoma and central retinal artery occlusion
Although central retinal artery occlusion (CRAO) has its own defining pathomechanism and clinical characteristics, morphologic feature of the optic nerve head (ONH) during its later stage is not diagnostic, wh...
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Open AccessGastrointestinal/genitourinary perforation and fistula formation with or without bevacizumab in patients with previously irradiated recurrent cervical cancer: a Korean multicenter retrospective study of the Gynecologic Oncology Research Investigators Collaboration (GORILLA) group (GORILLA-1001)
This study aims to evaluate the incidence of and identify risk factors for gastrointestinal (GI) and genitourinary (GU) fistula or perforation formation with or without bevacizumab in patients with recurrent c...
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Article
Development of an in vitro screening system for synthetic signal peptide in mammalian cell-based protein production
Optimizing appropriate signal peptides in mammalian cell-based protein production is crucial given that most recombinant proteins produced in mammalian cells are thought to be secreted proteins. Until now, mos...
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Article
Open AccessHuman neural stem cell-derived extracellular vesicles protect against Parkinson’s disease pathologies
Neural stem cells (NSCs) have the ability to generate a variety of functional neural cell types and have a high potential for neuronal cell regeneration and recovery. Thus, they been recognized as the best sou...
