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  1. Article

    Open Access

    A comparison of Illumina and Ion Torrent sequencing platforms in the context of differential gene expression

    Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability of Ion Torrent has left scientists wondering which platform is most effective for differential gene expression (DGE) analy...

    Nicholas F. Lahens, Emanuela Ricciotti, Olga Smirnova, Erik Toorens… in BMC Genomics (2017)

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  2. No Access

    Article

    Characterization and engineering of the ethylmalonyl-CoA pathway towards the improved heterologous production of polyketides in Streptomyces venezuelae

    Streptomyces venezuelae has an inherent advantage as a heterologous host for polyketide production due to its fast rate of growth that cannot be endowed easily through metabolic engineeri...

    Won Seok Jung, Eunji Kim, Young Ji Yoo… in Applied Microbiology and Biotechnology (2014)

  3. No Access

    Article

    Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes

    Bioactive natural products, such as polyketides, flavonoids, glycopeptides, and aminoglycosides, have been used as therapeutic agents. Many of them contain structurally diverse sugar moieties attached to the a...

    Myoung Chong Song, Eunji Kim, Yeon Hee Ban… in Applied Microbiology and Biotechnology (2013)

  4. No Access

    Article

    Study of genetic diversity and relationships among accessions of foxtail millet [Setaria italica (L.) P. Beauv.] in Korea, China, and Pakistan using SSR markers

    In this study, 28 simple sequence repeat (SSR) primer sets were used to analyze the genetic diversity, population structure, and genetic relationships among 37 accessions of foxtail millet from Korea, China an...

    Eun Ji Kim, Kyu ** Sa, Kyong-Cheul Park, Ju Kyong Lee in Genes & Genomics (2012)

  5. No Access

    Article

    Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities

    A 14-membered macrolide antibiotic narbomycin produced from Streptomyces venezuelae ATCC 15439 is composed of polyketide macrolactone ring and D-desosamine as a deoxysugar moiety, which acts as an important deter...

    Ah Reum Han, Pramod B. Shinde, Je Won Park… in Applied Microbiology and Biotechnology (2012)

  6. No Access

    Article

    A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253

    Rapamycin is a macrocyclic polyketide with immunosuppressive, antifungal, and anticancer activity produced by Streptomyces hygroscopicus ATCC 29253. Rapamycin production by a mutant strain (UV2-2) induced by ultr...

    Won Seok Jung, Young Ji Yoo, Je Won Park… in Applied Microbiology and Biotechnology (2011)

  7. No Access

    Article

    Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects

    Polyketides comprise one of the major families of natural products. They are found in a wide variety of bacteria, fungi, and plants and include a large number of medically important compounds. Polyketides are ...

    Sung Ryeol Park, Ah Reum Han, Yeon-Hee Ban… in Applied Microbiology and Biotechnology (2010)

  8. No Access

    Article

    Heterologous production of epothilones B and D in Streptomyces venezuelae

    Epothilones, produced from the myxobacterium Sorangium cellulosum, are potential anticancer agents that stabilize microtubules in a similar manner to paclitaxel. The entire epothilone biosynthetic gene cluster wa...

    Sung Ryeol Park, Je Won Park, Won Seok Jung… in Applied Microbiology and Biotechnology (2008)