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Article
Open AccessIn vitro antifungal and physicochemical properties of polymerized acrylic resin containing strontium-modified phosphate-based glass
Acrylic resins are widely used as the main components in removable orthodontic appliances. However, poor oral hygiene and maintenance of orthodontic appliances provide a suitable environment for the growth of ...
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Article
Open AccessRole of SYT11 in human pan-cancer using comprehensive approaches
Synaptotagmin 11 (SYT11) plays a pivotal role in neuronal vesicular trafficking and exocytosis. However, no independent prognostic studies have focused on various cancers. In this study, we aimed to summarize ...
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Article
Cough Response to High-Dose Inhaled Corticosteroids in Patients with Chronic Cough and Fractional Exhaled Nitric Oxide Levels ≥ 25 ppb: A Prospective Study
This study aimed to investigate the effects of high-dose inhaled corticosteroids (ICS) on chronic cough patients with elevated fractional exhaled nitric oxide (FeNO) levels. In a prospective study, adults with...
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Article
In vitro Fertilization Outcomes of Frozen–thawed Embryo Transfer with Hatched Blastocysts versus with Hatching Blastocysts
This study aimed to elucidate the effect of hatching status on in vitro fertilization (IVF) outcomes in frozen–thawed blastocyst transfer cycles. Frozen–thawed embryo transfer (FET) cycles performed at a single f...
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Article
Synergistic interaction of co-exposure to humidifier disinfectant chemicals CMIT/MIT and PHMG in lung injury
A number of biocidal disinfectant chemicals are used as household products to prevent spread of pathogens. People are commonly exposed to multiple chemicals through those disinfectants. However, effects of int...
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Article
Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
Codeine is a narcotic antitussive often considered for managing patients with refractory or unexplained chronic cough. This study aimed to evaluate the proportion and characteristics of patients who responded ...
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Article
Open AccessThe LKB1–TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway
The Hippo pathway’s main effector, Yes-associated protein (YAP), plays a crucial role in tumorigenesis as a transcriptional coactivator. YAP’s phosphorylation by core upstream components of the Hippo pathway, ...
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Article
Open AccessExposures to humidifier disinfectant and various health conditions in Korean based on personal exposure assessment data of claimants for compensation
Humidifier disinfectants (HDs) were commonly used household chemicals to prevent microbial growth in a humidifier water tank in South Korea. A growing body of evidence has indicated that its airborne exposure ...
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Article
Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study
The Korean Chronic Cough Registry study was initiated to characterize patients with chronic cough (CC) and investigate their outcomes in real-world clinical practice. This report aims to describe the baseline ...
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Article
Open AccessAnti-atopic dermatitis effect of fish collagen on house dust mite-induced mice and HaCaT keratinocytes
Collagen, a major structural protein in mammalian tissues, is effective against skin wounds and osteoarthritis. Although bovine and porcine collagens have mainly been used, several potential risks of mammalian...
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Article
Open AccessDimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways
Itaconate, a crucial immunometabolite, plays a critical role in linking immune and metabolic functions to influence host defense and inflammation. Due to its polar structure, the esterified cell-permeable deri...
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Article
Open AccessChemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling
The Arg/N-degron pathway, which is involved in the degradation of proteins bearing an N-terminal signal peptide, is connected to p62/SQSTM1-mediated autophagy. However, the impact of the molecular link between...
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Chapter and Conference Paper
Real-Time Pressure Feedback Sensor Designed for Manual Therapy—A Pilot Clinical Feasibility Study
Manual therapy is an evidence-based treatment technique that manual pressure of physical therapists is applied to the symptomatic body parts such as spine, soft tissue, and joints for treatment purposes. Altho...
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Article
Open AccessDysregulated thrombospondin 1 and miRNA-29a-3p in severe COVID-19
Although nearly a fifth of symptomatic COVID-19 patients suffers from severe pulmonary inflammation, the mechanism of develo** severe illness is not yet fully understood. To identify significantly altered ge...
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Article
Open AccessTargeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation
Acute myeloid leukemia (AML) is an aggressive blood cancer with poor clinical outcomes. Emerging data suggest that mitochondrial oxidative phosphorylation (mtOXPHOS) plays a significant role in AML tumorigenes...
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Article
Open AccessTranscriptomic analysis in the striatum reveals the involvement of Nurr1 in the social behavior of prenatally valproic acid-exposed male mice
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that exhibits neurobehavioral deficits characterized by abnormalities in social interactions, deficits in communication as well as restricted int...
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Article
Open AccessThe dual role of autophagy in acute myeloid leukemia
Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a lysosome-dependent ca...
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Article
Open AccessMisclassification and characterization of exposure to humidifier disinfectants using a questionnaire
Lung disease caused by exposure to chemical substances such as polyhexamethylene guanidine (PHMG) used in humidifier disinfectants (HDs) has been identified in Korea. Several researchers reported that exposure...
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Article
Open AccessMitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
Mitochondrial function and innate immunity are intimately linked; however, the mechanisms how mitochondrion-sha** proteins regulate innate host defense remains largely unknown. Herein we show that mitofusin-...
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Article
Open AccessComparison of murine retroorbital plexus and facial vein blood collection to mitigate animal ethics issues
Blood collection is an important procedure used in animal experiments. Blood collection methods that reduce pain, injury, and stress in experimental animals are important with regard to animal ethics. Various ...
