10 Result(s)
within
Eugene Kim
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAuthor Correction: Testing pseudotopological and nontopological models for SMC-driven DNA loop extrusion against roadblock-traversal experiments
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Article
Open AccessTesting pseudotopological and nontopological models for SMC-driven DNA loop extrusion against roadblock-traversal experiments
DNA loop extrusion by structural-maintenance-of-chromosome (SMC) complexes has emerged as a primary organizing principle for chromosomes. The mechanism by which SMC motor proteins extrude DNA loops is still un...
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Open AccessThe Smc5/6 complex is a DNA loop-extruding motor
Structural maintenance of chromosomes (SMC) protein complexes are essential for the spatial organization of chromosomes1. Whereas cohesin and condensin organize chromosomes by extrusion of DNA loops, the molecula...
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Open AccessRelevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocere...
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Open AccessSimultaneous orientation and 3D localization microscopy with a Vortex point spread function
Estimating the orientation and 3D position of rotationally constrained emitters with localization microscopy typically requires polarization splitting or a large engineered Point Spread Function (PSF). Here we...
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Open AccessIn vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease
Amyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitorin...
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Open AccessGraphene oxide/mussel foot protein composites for high-strength and ultra-tough thin films
Graphene oxide (GO)-based composite materials have become widely popular in many applications due to the attractive properties of GO, such as high strength and high electrical conductivity at the nanoscale. Mo...
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Open AccessNeuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study
Reperfusion is the only existing strategy for patients with acute ischemic stroke, however it causes further brain damage itself. A feasible therapy targeting reperfusion injury is remote ischemic conditioning...
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DNA-loop extruding condensin complexes can traverse one another
Condensin, a key component of the structure maintenance of chromosome (SMC) protein complexes, has recently been shown to be a motor that extrudes loops of DNA1. It remains unclear, however, how condensin complex...
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Open AccessTumor Ensemble-Based Modeling and Visualization of Emergent Angiogenic Heterogeneity in Breast Cancer
There is a critical need for new tools to investigate the spatio-temporal heterogeneity and phenotypic alterations that arise in the tumor microenvironment. However, computational investigations of emergent in...
