7 Result(s)
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Article
Clinical value of DNA methylation markers in autoimmune rheumatic diseases
Methylation of cytosine residues in DNA, the best studied epigenetic modification, is associated with gene transcription and nuclear organization, and ultimately the function of a cell. DNA methylation can be ...
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Chapter
Epigenetics in Autoinflammation
The molecular mechanisms of inflammation involve a series of processes that start as extracellular signals that interact with membrane-bound receptors, cell signaling cascades, nuclear factors, and epigenetic ...
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Article
New insights into the epigenetics of inflammatory rheumatic diseases
Epigenetic mechanisms are essential for immune cell differentiation and function, including the correct activation of B cells and T cells and inflammatory proc...
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Article
DNA methylation signatures in Sjögren syndrome
Changes in DNA methylation patterns are emerging as an important feature in the development and progression of primary Sjögren syndrome. However, questions remain regarding the contribution of epigenetic (and ...
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Article
Insights into RA pathogenesis from DNA methylome analysis
Could temporal changes in DNA methylation patterns of rheumatoid arthritis (RA) synoviocytes provide insights into the progression of the disease? A study comparing synoviocyte DNA methylation profiles in earl...
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Article
Epigenetic alterations in autoimmune rheumatic diseases
The potential of epigenetics to explain the complex links between environmental triggers and genetic susceptibility is captivating researchers in many diseases. As this article describes, considerable evidence...
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Article
Epigenetics Lessons from Twins: Prospects for Autoimmune Disease
The existence of phenotypic differences between monozygotic (MZ) twins is a prime case where the relationship between genetic determinants and environmental factors is illustrated. Although virtually identical...
