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Article

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Alzheimer’s disease (AD), the leading cause of dementia, has an estimated heritability of approximately 70%¹. The genetic component of AD has been mainly assessed using genome-wide association studies, which do n...

Henne Holstege, Marc Hulsman, Camille Charbonnier… in Nature Genetics (2022)