4 Result(s)
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Article
Open AccessThe role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study
Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derive...
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Article
Open AccessLife course plasma metabolomic signatures of genetic liability to Alzheimer’s disease
Mechanisms through which most known Alzheimer’s disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD ...
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Article
Open AccessThe causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of...
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Article
Open AccessLittle genomic support for Cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriers
Therapeutic targets for halting the progression of Alzheimer’s disease pathology are lacking. Recent evidence suggests that APOE4, but not APOE3, activates the Cyclophilin-A matrix metalloproteinase-9 (CypA-MM...
