11 Result(s)
within
Emma L. Anderson
English
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Article
Open AccessThe role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study
Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derive...
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Open AccessLife course plasma metabolomic signatures of genetic liability to Alzheimer’s disease
Mechanisms through which most known Alzheimer’s disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD ...
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Open AccessInvestigation of genetic determinants of cognitive change in later life
Cognitive decline is a major health concern and identification of genes that may serve as drug targets to slow decline is important to adequately support an aging population. Whilst genetic studies of cross-se...
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Open AccessA brief comparison of polygenic risk scores and Mendelian randomisation
Mendelian randomisation and polygenic risk score analysis have become increasingly popular in the last decade due to the advent of large-scale genome-wide association studies. Each approach has valuable applic...
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Drug target Mendelian randomisation: are we really instrumenting drug use?
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Open AccessExploring the causal effects of genetic liability to ADHD and Autism on Alzheimer’s disease
Few studies suggest possible links between attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and Alzheimer’s disease but they have been limited by small sample sizes, diagnostic a...
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Open AccessThe causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of...
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Open AccessLittle genomic support for Cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriers
Therapeutic targets for halting the progression of Alzheimer’s disease pathology are lacking. Recent evidence suggests that APOE4, but not APOE3, activates the Cyclophilin-A matrix metalloproteinase-9 (CypA-MM...
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Open AccessGenomic analysis of diet composition finds novel loci and associations with health and lifestyle
We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique...
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Article
Open AccessProspective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood: the MRC National Survey of Health and Development
Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors i...
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Open AccessThe Active for Life Year 5 (AFLY5) school-based cluster randomised controlled trial: effect on potential mediators
Active for life year 5 (AFLY5) is a school-based intervention, based on social cognitive theory, which aims to promote healthy levels of physical activity and healthy eating by improving a child’s self-efficac...
