6 Result(s)
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Article
Open AccessInvestigation of genetic determinants of cognitive change in later life
Cognitive decline is a major health concern and identification of genes that may serve as drug targets to slow decline is important to adequately support an aging population. Whilst genetic studies of cross-se...
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Article
Drug target Mendelian randomisation: are we really instrumenting drug use?
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Open AccessExploring the causal effects of genetic liability to ADHD and Autism on Alzheimer’s disease
Few studies suggest possible links between attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and Alzheimer’s disease but they have been limited by small sample sizes, diagnostic a...
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Article
Open AccessGenomic analysis of diet composition finds novel loci and associations with health and lifestyle
We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique...
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Open AccessProspective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood: the MRC National Survey of Health and Development
Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors i...
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Article
Open AccessThe Active for Life Year 5 (AFLY5) school-based cluster randomised controlled trial: effect on potential mediators
Active for life year 5 (AFLY5) is a school-based intervention, based on social cognitive theory, which aims to promote healthy levels of physical activity and healthy eating by improving a child’s self-efficac...
