6 Result(s)

Article

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some...

Kevin Litchfield, James L. Reading, Emilia L. Lim, Hang Xu, Po Liu… in Nature Communications (2020)

Article

Genomic–transcriptomic evolution in lung cancer and metastasis

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy¹. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcript...

Carlos Martínez-Ruiz, James R. M. Black, Clare Puttick, Mark S. Hill… in Nature (2023)

Article

The evolution of non-small cell lung cancer metastases in TRACERx

Metastatic disease is responsible for the majority of cancer-related deaths¹. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited pa...

Maise Al Bakir, Ariana Huebner, Carlos Martínez-Ruiz, Kristiana Grigoriadis… in Nature (2023)

Article

The evolution of lung cancer and impact of subclonal selection in TRACERx

Lung cancer is the leading cause of cancer-associated mortality worldwide¹. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer...

Alexander M. Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L. Lim… in Nature (2023)

Article

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)^1,2. Although TLS have been found to correlate with improved...

Kevin W. Ng, Jesse Boumelha, Katey S. S. Enfield, Jorge Almagro, Hongui Cha… in Nature (2023)

Article

Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx

Alexander M. Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L. Lim… in Nature (2024)